Herein, we report a conceptually new, general, and efficient approach for the synthesis of valuable ortho‐azido‐1,5‐disubstituted tetrazole and one‐pot synthesis of ortho‐triazoletetrazole derivatives mainly via PIDA mediated N‐N cleavage of the azole ring of 2H‐indazoles using TMSN3. This current methodology represents an array of unsymmetrical ortho‐azidotetrazole and ortho‐triazoletetrazole derivatives

A variety of structurally diverse spirocyclohexane oxindoles featuring a quaternary carbon centre have been successfully constructed through an N‐heterocyclic carbene‐catalyzed [4+2] annulation of isatin‐derived enals with α cyano‐β‐methylenones. This domino process exhibits a wide substrate tolerance, operates under mild conditions, and yields products with high enantioselectivity.

A new strategy for the construction of chiral 4H‐chromene skeleton via Pd‐catalyzed asymmetric amination of 2H‐chromene was reported. A series of chiral 2‐trifluoromethyl‐4H‐chromenes containing 1,2,3,4‐tetrahydroquinoline unit were synthesized in moderate to good yields with excellent enantioselectivity, the method serves as an effective supplement to the construction of chiral 4H‐chromene skeleton

This work provides an in‐depth analysis of the factors governing the different reaction pathways in the acid‐catalyzed cyclization of gem‐vinylsilyl alcohols with aldehydes. The study evaluates the impact of both the ligands attached to silicon and the choice of the Lewis acid on the reaction outcome. Additionally, computational studies offer valuable insights into the mechanism that control these

β‐pyridinyl ketones and β‐pyridinyl thiocyanates are commonly used as an essential organic synthesis intermediate and widely present in various drug molecules and bioactive molecules. Herein, a photoredox catalyzed acyl and thiocyano pyridylation of alkenes with aldehydes and NH4SCN via HAT and SET strategy respectively is described. This protocol employs more readily accessible aldehydes and NH4SCN

Herein, we disclose a new photochemical process to prepare γ‐amino acids from allylamines and formic acid salts. The investigated redox‐neutral hydrocarboxylation process produces high yields across a wide range of functionalized allylamine substrates with excellent regioselectivity. The developed operationally simple protocol can be readily scaled with low photocatalyst loading (from 1% up to 0.02

Arenes, especially heteroarenes, are crucial structural motifs in organic chemistry, pharmaceutical chemistry, and materials science. The introduction of (hetero)aryl groups using readily available feedstocks to modify organic chemicals is a significant topic. Nitriles are ubiquitous and versatile building blocks in organic synthesis. This article summarizes recent advances in decyanative arylation

The visible light‐induced one‐pot tandem photolysis of areneazo‐2‐(2‐nitro)propanes was achieved to give carbazole and indole derivatives. The aryl azidation followed by an intramolecular C−H amination smoothly proceeded under visible light irradiation without any photocatalyst, demonstrating the synthetic versatility of areneazo‐2‐(2‐nitro)propanes. The in situ generation of aryl azide intermediates

Development of a mild approach for the highly efficient synthesis of 2‐aryl azoles, which are typically synthesized using high temperature, ligands and preactivated substrates, is highly desirable. Here, we report a mild and efficient photo‐induced Cu‐catalyzed C–H/C–H cross‐coupling to obtain C2‐functionalized azoles using aryl thianthrenium salt (Ar‐TTs). The reaction exhibits a broad substrate scope

Herein, we report a novel and practical strategy to access α‐chloroketones from esters bearing diverse (hetero)aromatic, aliphatic, alkynyl and alkenyl substituents with transient chloromethyllithium under continuous flow conditions. This highly chemoselective method enables a fast (on a time scale of <5 s), efficient and straightforward access to a broad substrate scope (up to 99% yield) with a remarkable

The chromium‐catalysed Nozaki‐Hiyama‐Kishi (NHK) reaction is a very dependable technique for alcohol synthesis and is extensively used in the complete synthesis of natural compounds. The majority of these reactions occur via a reductive‐radical‐polar crossover (RRPCO) mechanism, which is crucial for the transformation of reactive radical intermediates. The production of radicals using photoinduced

Phenylalanine ammonia lyase (PAL) enzymes have been extensively exploited to produce differently substituted arylalanine analogues, but their use in the stereoselective synthesis of aliphatic fatty amino acids has never been addressed. In this work, a two‐step hydroamination‐hydrodesulfurisation process has been investigated for the production of aliphatic L‐α‐amino acids from thienylacrylic acids

Herein we reported a manganese promoted reductive cross‐coupling approach to construct P‒S bond. This is a practical method for the synthesis of mono‐thiophosphanes, bis‐thiophosphanes and tri‐thiophosphanes under mild conditions. The strategy featured a wide range of substrate scope including various disulfides and phosphine chlorides, constructing diverse sulfur‐containing organophosphorus compounds

A copper-catalyzed carbo-/protoboration of boryl enynes is disclosed, providing access to an array of penta- and hexasubstituted diboryl dienes in a chemo-, regio- and stereoselective manner. All six positions of the dienes can be manipulated using this methodology. The hexasubstituted diene boronates adopt a skew conformation. An iterative Suzuki coupling of the products provided highly conjugated

Benzylidene imidazolones with an ortho-sec-amino group undergo chemodivergent photochemical transformations, based on the wavelength of irradiation. Irradiation at 525 nm causes dimerization and the formation of cyclobutanes with two spiroatoms, related to dictazoles in 87–98% yield. In turn, irradiation at 365 nm provides access to spirocyclic indolines in 67–92% yield. Each of the processes proceeds