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Encorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2025-01-25 Scott Kopetz, Takayuki Yoshino, Eric Van Cutsem, Cathy Eng, Tae Won Kim, Harpreet Singh Wasan, Jayesh Desai, Fortunato Ciardiello, Rona Yaeger, Timothy S. Maughan, Elena Beyzarov, Xiaoxi Zhang, Graham Ferrier, Xiaosong Zhang, Josep Tabernero
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Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial Nat. Med. (IF 58.7) Pub Date : 2025-01-24 Christian Kurzeder, Bich Doan Nguyen-Sträuli, Ilona Krol, Alexander Ring, Francesc Castro-Giner, Manuel Nüesch, Simran Asawa, Yu Wei Zhang, Selina Budinjas, Ana Gvozdenovic, Maren Vogel, Angela Kohler, Cvetka Grašič Kuhar, Fabienne D. Schwab, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz, Denise Vorburger, Heike Frauchiger-Heuer, Isabell Witzel, Andreas Wicki, Gabriela M. Kuster
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Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria Nat. Med. (IF 58.7) Pub Date : 2025-01-24 Caitlin Bond, Olivia J. Bednarski, Dibyadyuti Datta, Ruth Namazzi, Robert O. Opoka, Giselle Lima-Cooper, Anthony Batte, Keerthi Udumula, Deepali Balasubramani, Marilyn Vasquez, Ana Rodriguez, Claire Liepmann, Paul Bangirana, Marco Abreu, Tae-Hwi Schwantes-An, Yi Zhao, Tarek M. El-Achkar, Nathan W. Schmidt, Chandy C. John, Andrea L. Conroy
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Author Correction: Propagative α-synuclein seeds as serum biomarkers for synucleinopathies Nat. Med. (IF 58.7) Pub Date : 2025-01-24 Ayami Okuzumi, Taku Hatano, Gen Matsumoto, Shuko Nojiri, Shin-ichi Ueno, Yoko Imamichi-Tatano, Haruka Kimura, Soichiro Kakuta, Akihide Kondo, Takeshi Fukuhara, Yuanzhe Li, Manabu Funayama, Shinji Saiki, Daisuke Taniguchi, Taiji Tsunemi, Deborah McIntyre, Jean-Jacques Gérardy, Michel Mittelbronn, Rejko Kruger, Yasuo Uchiyama, Nobuyuki Nukina, Nobutaka Hattori
Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02358-9, published online 29 May 2023.
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Imatinib and the dawn of precision cancer therapy Nat. Med. (IF 58.7) Pub Date : 2025-01-23
Brian J. Druker describes how his research on imatinib validated protein kinases as therapeutic targets for cancer and led to a life-saving treatment for leukemia.
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Unlocking the broad health benefits and risks of GLP-1 receptor agonist drugs Nat. Med. (IF 58.7) Pub Date : 2025-01-23
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The Future of Medicine Nat. Med. (IF 58.7) Pub Date : 2025-01-22
As Nature Medicine celebrates its 30th anniversary, we reflect on the challenges ahead and what the future holds for medicine — and for our journal.
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The Access to Dialysis in Low- and Middle-Income Countries Commission: lessons for universal health coverage Nat. Med. (IF 58.7) Pub Date : 2025-01-22 Yot Teerawattananon, Kinanti Khansa Chavarina, Jeerath Phannajit, Jiratorn Sutawong, Natcha Yongphiphatwong, Sydney C. W. Tang, Talerngsak Kanjanabuch, Tanainan Chuanchaiyakul, Thunyarat Anothaisintawee, Valerie Luyckx, Wanrudee Isaranuwatchai, Kearkiat Praditpornsilpa, Kriang Tungsanga, Vivekanand Jha
Announced in this Comment and in collaboration with Nature Medicine is the convening of the Access to Dialysis in Low- and Middle-Income Countries Commission, which will explore Thailand’s experiences with changing its dialysis coverage policy, offering lessons for other countries with universal health coverage systems.
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The Quality Health Information for All Commission: reinventing health communication for the digital era Nat. Med. (IF 58.7) Pub Date : 2025-01-22 Scott C. Ratzan, Heidi J. Larson, Carolina Batista, Aleksandra Kuzmanovic, Paul E. Kalb, Kenneth H. Rabin, Lawrence O. Gostin
Announced in this Comment and in collaboration with Nature Medicine is the convening of the Quality Health Information for All Commission, to promote equitable access to quality health information from trusted sources and affirm the practice of health communication as a distinct public health discipline.
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First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2025-01-22 Lin Shen, Yanqiao Zhang, Ziyu Li, Xiaotian Zhang, Xiangyu Gao, Bo Liu, Yusheng Wang, Yi Ba, Ning Li, Ruixing Zhang, Jingdong Zhang, Ye Chen, Jian Chen, Mingzhu Huang, Yang Fu, Mulin Liu, Zheng Liu, Jun Zhao, Wei Li, Jia Wei, Changzheng Li, Nong Xu, Zengqing Guo, Bangwei Cao, Lian Liu, Peng Nie, Lixin Wan, Lili Sheng, Zhenyang Liu, Yifu He, Kangsheng Gu, Guowu Wu, Weibo Wang, Futong Zhang, Wensheng
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Our Future Health: a unique global resource for discovery and translational research Nat. Med. (IF 58.7) Pub Date : 2025-01-21 Michael B. Cook, Saskia C. Sanderson, John E. Deanfield, Fiona Reddington, Andrew Roddam, David J. Hunter, Raghib Ali
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Neoadjuvant nivolumab and chemotherapy in early estrogen receptor-positive breast cancer: a randomized phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2025-01-21 Sherene Loi, Roberto Salgado, Giuseppe Curigliano, Roberto Iván Romero Díaz, Suzette Delaloge, Carlos Ignacio Rojas García, Marleen Kok, Cristina Saura, Nadia Harbeck, Elizabeth A. Mittendorf, Denise A. Yardley, Alberto Suárez Zaizar, Facundo Rufino Caminos, Andrei Ungureanu, Joaquin G. Reinoso-Toledo, Valentina Guarneri, Daniel Egle, Felipe Ades, Misena Pacius, Aparna Chhibber, Rajalakshmi Chandra
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Pembrolizumab and chemotherapy in high-risk, early-stage, ER+/HER2− breast cancer: a randomized phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2025-01-21 Fatima Cardoso, Joyce O’Shaughnessy, Zhenzhen Liu, Heather McArthur, Peter Schmid, Javier Cortes, Nadia Harbeck, Melinda L. Telli, David W. Cescon, Peter A. Fasching, Zhimin Shao, Delphine Loirat, Yeon Hee Park, Manuel Gonzalez Fernandez, Gábor Rubovszky, Laura Spring, Seock-Ah Im, Rina Hui, Toshimi Takano, Fabrice André, Hiroyuki Yasojima, Yu Ding, Liyi Jia, Vassiliki Karantza, Konstantinos Tryfonidis
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The expanding repertoire of brain–computer interfaces Nat. Med. (IF 58.7) Pub Date : 2025-01-20 Nick F. Ramsey, Mariska J. Vansteensel
Brain–computer interfaces are expanding from functional to recreational applications, as evidenced by a study in which a person with tetraplegia controlled a recreational virtual drone, but their clinical utility is still uncertain.
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Prenatal blood tests can reveal maternal cancer Nat. Med. (IF 58.7) Pub Date : 2025-01-20
A study detected hidden cancers in almost half of all pregnant people who were referred for cancer screening following an abnormal or unreportable prenatal blood test result.
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A high-performance brain–computer interface for finger decoding and quadcopter game control in an individual with paralysis Nat. Med. (IF 58.7) Pub Date : 2025-01-20 Matthew S. Willsey, Nishal P. Shah, Donald T. Avansino, Nick V. Hahn, Ryan M. Jamiolkowski, Foram B. Kamdar, Leigh R. Hochberg, Francis R. Willett, Jaimie M. Henderson
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Mapping the effectiveness and risks of GLP-1 receptor agonists Nat. Med. (IF 58.7) Pub Date : 2025-01-20 Yan Xie, Taeyoung Choi, Ziyad Al-Aly
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Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids Nat. Med. (IF 58.7) Pub Date : 2025-01-21 Mattia Francesco Maria Gerli, Giuseppe Calà, Max Arran Beesley, Beatrice Sina, Lucinda Tullie, Kylin Yunyan Sun, Francesco Panariello, Federica Michielin, Joseph R. Davidson, Francesca Maria Russo, Brendan C. Jones, Dani Do Hyang Lee, Savvas Savvidis, Theodoros Xenakis, Ian C. Simcock, Anna A. Straatman-Iwanowska, Robert A. Hirst, Anna L. David, Christopher O’Callaghan, Alessandro Olivo, Simon Eaton
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-02807-z, published online 4 March 2024.
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Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies Nat. Med. (IF 58.7) Pub Date : 2025-01-20 Julie K. Jadlowsky, Elizabeth O. Hexner, Amy Marshall, Stephan A. Grupp, Noelle V. Frey, James L. Riley, Elizabeth Veloso, Holly McConville, Walter Rogal, Cory Czuczman, Wei-Ting Hwang, Yimei Li, Rachel M. Leskowitz, Olivia Farrelly, Jayashree Karar, Shannon Christensen, Julie Barber-Rotenberg, Avery Gaymon, Naomi Aronson, Wendy Bernstein, Jan Joseph Melenhorst, Aoife M. Roche, John K. Everett, Sonja
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Artificial intelligence in drug development Nat. Med. (IF 58.7) Pub Date : 2025-01-20 Kang Zhang, Xin Yang, Yifei Wang, Yunfang Yu, Niu Huang, Gen Li, Xiaokun Li, Joseph C. Wu, Shengyong Yang
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Data sharing restrictions are hampering precision health in the European Union Nat. Med. (IF 58.7) Pub Date : 2025-01-17 Cristina Legido-Quigley, Nicolai J. Wewer Albrechtsen, Martin Bæk Blond, Marcelo Corrales Compagnucci, Madeleine Ernst, Markus J. Herrgård, Timo Minssen, Filip Ottosson, Flemming Pociot, Peter Rossing, Karolina Sulek
Contemporary healthcare is undergoing a transition, shifting from a population-based approach to personalized medicine on an individual level1. In October 2023, the European Partnership for Personalized Medicine was officially launched2 to communicate the benefits of this approach to citizens and healthcare systems in member countries. The main debate revolves around the inconsistency in regulatory
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How patient advocates influence health policy Nat. Med. (IF 58.7) Pub Date : 2025-01-17 Elizabeth Kasimu Mutunga
Scientists can learn the power of storytelling and coalition-building from patient advocates.
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Clinically useful obesity subtypes revealed by harnessing deviations from population-average risk Nat. Med. (IF 58.7) Pub Date : 2025-01-17
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Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis Nat. Med. (IF 58.7) Pub Date : 2025-01-17 Rachael I. Scahill, Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Christelle Langley, Harry Knights, Marc Ciosi, Kate Fayer, Mitsuko Nakajima, Olivia Thackeray, Johan Gobom, John Rönnholm, Sophia Weiner, Yara R. Hassan, Nehaa K. P. Ponraj, Carlos Estevez-Fraga, Christopher S. Parker, Ian B. Malone, Harpreet Hyare, Jeffrey D. Long, Amanda Heslegrave, Cristina Sampaio, Hui Zhang, Trevor
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Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial Nat. Med. (IF 58.7) Pub Date : 2025-01-17 Alicia F. C. Okines, Giuseppe Curigliano, Nobumasa Mizuno, Do-Youn Oh, Andree Rorive, Hatem Soliman, Shunji Takahashi, Tanios Bekaii-Saab, Mark E. Burkard, Ki Y. Chung, Philip R. Debruyne, Jenny R. Fox, Valentina Gambardella, Marta Gil-Martin, Erika P. Hamilton, Bradley J. Monk, Yoshiaki Nakamura, Danny Nguyen, David M. O’Malley, Alexander B. Olawaiye, Bhavana Pothuri, Martin Reck, Kazuki Sudo, Yu
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Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses Nat. Med. (IF 58.7) Pub Date : 2025-01-17 Steven Laurie, Wouter Steyaert, Elke de Boer, Kiran Polavarapu, Nika Schuermans, Anna K. Sommer, German Demidov, Kornelia Ellwanger, Ida Paramonov, Coline Thomas, Stefan Aretz, Jonathan Baets, Elisa Benetti, Gemma Bullich, Patrick F. Chinnery, Jill Clayton-Smith, Enzo Cohen, Daniel Danis, Jean-Madeleine de Sainte Agathe, Anne-Sophie Denommé-Pichon, Jordi Diaz-Manera, Stephanie Efthymiou, Laurence Faivre
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Global health engagement strengthens US security, prosperity and leadership Nat. Med. (IF 58.7) Pub Date : 2025-01-17
Discover the world’s best science and medicine | Nature.com
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Publisher Correction: Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease Nat. Med. (IF 58.7) Pub Date : 2025-01-16 Oveis Jamialahmadi, Antonio De Vincentis, Federica Tavaglione, Francesco Malvestiti, Ruifang Li-Gao, Rosellina M. Mancina, Marcus Alvarez, Kyla Gelev, Samantha Maurotti, Umberto Vespasiani-Gentilucci, Frits Richard Rosendaal, Julia Kozlitina, Päivi Pajukanta, François Pattou, Luca Valenti, Stefano Romeo
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03284-0, published online 9 December 2024.
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Menstrual cycle linked to breast cancer chemotherapy response Nat. Med. (IF 58.7) Pub Date : 2025-01-15
According to preclinical studies and a retrospective clinical analysis, the menstrual cycle may influence the breast cancer response to neoadjuvant chemotherapy — suggesting that treatment could be timed for optimal outcomes.
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Donor-derived GD2-specific CAR T cells in relapsed or refractory neuroblastoma Nat. Med. (IF 58.7) Pub Date : 2025-01-15 Concetta Quintarelli, Francesca Del Bufalo, Maria Antonietta De Ioris, Marika Guercio, Mattia Algeri, Daria Pagliara, Domenico Alessandro Silvestris, Matteo Di Nardo, Matilde Sinibaldi, Stefano Di Cecca, Laura Iaffaldano, Simona Manni, Valentina Fustaino, Maria Carmen Garganese, Giovanna Stefania Colafati, Valentina Bertaina, Marco Becilli, Angela Mastronuzzi, Francesco Fabozzi, Monica Gunetti, Stefano
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Health AI poses distinct harms and potential benefits for disabled people Nat. Med. (IF 58.7) Pub Date : 2025-01-14 Charles E. Binkley, Joel M. Reynolds, Andrew G. Shuman
Relative to other groups for whom the risk of bias in artificial intelligence (AI) has been identified, little attention has been given to the potential harms, and distinct benefits, that AI models could bring about for disabled people. Predictions made by AI models for disabled patients may lead to discrimination in at least three ways: disabled patients are underrepresented in datasets; they have
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In vivo base editing extends lifespan of a humanized mouse model of prion disease Nat. Med. (IF 58.7) Pub Date : 2025-01-14 Meirui An, Jessie R. Davis, Jonathan M. Levy, Fiona E. Serack, John W. Harvey, Pamela P. Brauer, Catherine P. Pirtle, Kiara N. Berríos, Gregory A. Newby, Wei-Hsi Yeh, Nikita Kamath, Meredith Mortberg, Yuan Lian, Michael Howard, Kendrick DeSouza-Lenz, Kenia Guzman, Aaron Thai, Samantha Graffam, Alissa A. Coffey, Jeannine Frei, Sarah E. Pierce, Jiri G. Safar, Benjamin E. Deverman, Eric Vallabh Minikel
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Differences in the lifetime risk and population burden of dementia Nat. Med. (IF 58.7) Pub Date : 2025-01-13
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Lifetime risk and projected burden of dementia Nat. Med. (IF 58.7) Pub Date : 2025-01-13 Michael Fang, Jiaqi Hu, Jordan Weiss, David S. Knopman, Marilyn Albert, B. Gwen Windham, Keenan A. Walker, A. Richey Sharrett, Rebecca F. Gottesman, Pamela L. Lutsey, Thomas Mosley, Elizabeth Selvin, Josef Coresh
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Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates Nat. Med. (IF 58.7) Pub Date : 2025-01-13 Robert W. Cross, Courtney Woolsey, Abhishek N. Prasad, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Mack B. Harrison, Natalie S. Dobias, Karla A. Fenton, Tomas Cihlar, Anh-Quan Nguyen, Darius Babusis, Roy Bannister, Meghan S. Vermillion, Victor C. Chu, Thomas W. Geisbert
The recent outbreak of Marburg virus (MARV) in Rwanda underscores the need for effective countermeasures against this highly fatal pathogen, with case fatality rates reaching 90%. Currently, no vaccines or approved treatments exist for MARV infection, distinguishing it from related viruses like Ebola. Our research demonstrates that the oral drug obeldesivir (ODV), a nucleoside analog prodrug, shows
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Author Correction: Ferric carboxymaltose for anemia in late pregnancy: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-01-13 Sant-Rayn Pasricha, Ernest Moya, Ricardo Ataíde, Glory Mzembe, Rebecca Harding, Martin N. Mwangi, Truwah Zinenani, Khic-Houy Prang, Justina Kaunda, Owen P. L. Mtambo, Maclean Vokhiwa, Gomezgani Mhango, Elisabeth Mamani-Mategula, Katherine Fielding, Ayşe Demir, Naomi Von Dinklage, Hans Verhoef, Alistair RD McLean, Lucinda Manda-Taylor, Sabine Braat, Kamija S. Phiri
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03385-w, published online 6 January 2025.
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Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma Nat. Med. (IF 58.7) Pub Date : 2025-01-13 James R. M. Black, Gabor Bartha, Charles W. Abbott, Sean M. Boyle, Takahiro Karasaki, Bailiang Li, Rui Chen, Jason Harris, Selvaraju Veeriah, Martina Colopi, Maise Al Bakir, Wing Kin Liu, John Lyle, Fábio C. P. Navarro, Josette Northcott, Rachel Marty Pyke, Mark S. Hill, Kerstin Thol, Ariana Huebner, Chris Bailey, Emma C. Colliver, Carlos Martínez-Ruiz, Kristiana Grigoriadis, Piotr Pawlik, David A
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How citizen scientists and community engagement boost the impact of health research Nat. Med. (IF 58.7) Pub Date : 2025-01-13
With the Declaration of Helsinki now mandating community engagement, Nature Medicine asks three winners of the Nature Awards for Inclusive Health Research to share their tips.
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RNA gene therapies offer hope for millions with high cholesterol Nat. Med. (IF 58.7) Pub Date : 2025-01-13
Base editing, antisense oligonucleotides and siRNA therapies that target low-density lipoprotein and the genes encoding molecules that regulate it are being tested in several clinical trials.
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Visualizing the effects and causes of caregiver deaths on children in the USA Nat. Med. (IF 58.7) Pub Date : 2025-01-10
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Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-01-10 Paul N. Brennan, Mark MacMillan, Thomas Manship, Francesca Moroni, Alison Glover, Debbie Troland, Iain MacPherson, Catriona Graham, Rhona Aird, Scott I. K. Semple, David M. Morris, Alasdair R. Fraser, Chloe Pass, Neil W. A. McGowan, Marc L. Turner, Lynn Manson, Neil J. Lachlan, John F. Dillon, Alastair M. Kilpatrick, John D. M. Campbell, Jonathan A. Fallowfield, Stuart J. Forbes
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Subcutaneous weekly semaglutide with automated insulin delivery in type 1 diabetes: a double-blind, randomized, crossover trial Nat. Med. (IF 58.7) Pub Date : 2025-01-10 Melissa-Rosina Pasqua, Michael A. Tsoukas, Alessandra Kobayati, Wedyan Aboznadah, Adnan Jafar, Ahmad Haidar
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Orphanhood and caregiver death among children in the United States by all-cause mortality, 2000–2021 Nat. Med. (IF 58.7) Pub Date : 2025-01-10 Andrés Villaveces, Yu Chen, Sydney Tucker, Alexandra Blenkinsop, Lucie Cluver, Lorraine Sherr, Jan L. Losby, Linden Graves, Rita Noonan, Francis Annor, Victor Kojey-Merle, Douhan Wang, Greta Massetti, Laura Rawlings, Charles A. Nelson, H. Juliette T. Unwin, Seth Flaxman, Susan Hillis, Oliver Ratmann
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Premarital genomic screening in Arab populations of the Middle East Nat. Med. (IF 58.7) Pub Date : 2025-01-09 Ikram Chekroun, Fatma Rabea, Ruchi Jain, Alawi Alsheikh-Ali, Ahmad Abou Tayoun
Premarital genomic screening can help curb the burden of rare recessive disorders in populations with high rates of consanguineous marriages. Arab populations of the Middle East have a unique genetic blend characterized by founder mutations due to historical bottlenecks, and diverse allelic series shaped by a long history of migrations and intermixing. The risk of homozygous pathogenic variants, which
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Impact of RSVpreF vaccination on reducing the burden of respiratory syncytial virus in infants and older adults Nat. Med. (IF 58.7) Pub Date : 2025-01-09 Zhanwei Du, Abhishek Pandey, Seyed M. Moghadas, Yuan Bai, Lin Wang, Laura Matrajt, Burton H. Singer, Alison P. Galvani
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Green cities for better health Nat. Med. (IF 58.7) Pub Date : 2025-01-08
Satellite data assessing residential greenness across Italy indicate that thousands of deaths could be prevented by greening residential areas.
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Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters Nat. Med. (IF 58.7) Pub Date : 2025-01-08
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T cell malignancies after CAR T cell therapy in the DESCAR-T registry Nat. Med. (IF 58.7) Pub Date : 2025-01-08 Remy Dulery, Vincent Guiraud, Sylvain Choquet, Catherine Thieblemont, Emmanuel Bachy, Stéphane Barete, Ève Todesco, Bertrand Arnulf, Nicolas Boissel, André Baruchel, Jacques-Olivier Bay, Steven Le Gouill, Roch Houot
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Transplantation of a genetically modified porcine heart into a live human Nat. Med. (IF 58.7) Pub Date : 2025-01-08 Bartley P. Griffith, Alison Grazioli, Avneesh K. Singh, Andy Tully, Javier Galindo, Kapil K. Saharia, Aakash Shah, Erik R. Strauss, Patrick N. Odonkor, Brittney Williams, Henry J. Silverman, Allen Burke, Cinthia B. Drachenberg, Chris L. Wells, Timm Dickfeld, Susie N. Hong, Albert J. Hicks, Manjula Ananthram, Anuj Gupta, Robert H. Christenson, Lo Tamburro, Tianshu Zhang, Alena Hershfeld, Billeta Lewis
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Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial Nat. Med. (IF 58.7) Pub Date : 2025-01-08 Emilie Combet, Laura Haag, Janice Richardson, Caroline E. Haig, Yvonne Cunningham, Heather L. Fraser, Naomi Brosnahan, Tracy Ibbotson, Jane Ormerod, Chris White, Emma McIntosh, Catherine A. O’Donnell, Naveed Sattar, Alex McConnachie, Michael E. J. Lean, David N. Blane
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The gut–brain axis underlying hepatic encephalopathy in liver cirrhosis Nat. Med. (IF 58.7) Pub Date : 2025-01-08 Xiaolong He, Mengyao Hu, Yi Xu, Fangbo Xia, Yang Tan, Yuqing Wang, Huiling Xiang, Hao Wu, Tengfei Ji, Qian Xu, Lei Wang, Zhenhe Huang, Meiling Sun, Yu Wan, Peng Cui, Shaocong Liang, Yuan Pan, Siyu Xiao, Yan He, Ruixin Song, Junqing Yan, Xin Quan, Yingge Wei, Changze Hong, Weizuo Liao, Fuli Li, Emad El-Omar, Jinjun Chen, Xiaolong Qi, Jie Gao, Hongwei Zhou
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High-efficiency base editing in the retina in primates and human tissues Nat. Med. (IF 58.7) Pub Date : 2025-01-08 Alissa Muller, Jack Sullivan, Wibke Schwarzer, Mantian Wang, Cindy Park-Windhol, Pascal W. Hasler, Lucas Janeschitz-Kriegl, Mert Duman, Beryll Klingler, Jane Matsell, Simon Manuel Hostettler, Patricia Galliker, Yanyan Hou, Pierre Balmer, Tamás Virág, Luis Alberto Barrera, Lauren Young, Quan Xu, Dániel Péter Magda, Ferenc Kilin, Arogya Khadka, Pierre-Henri Moreau, Lyne Fellmann, Thierry Azoulay, Mathieu
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The TRIPOD-LLM reporting guideline for studies using large language models Nat. Med. (IF 58.7) Pub Date : 2025-01-08 Jack Gallifant, Majid Afshar, Saleem Ameen, Yindalon Aphinyanaphongs, Shan Chen, Giovanni Cacciamani, Dina Demner-Fushman, Dmitriy Dligach, Roxana Daneshjou, Chrystinne Fernandes, Lasse Hyldig Hansen, Adam Landman, Lisa Lehmann, Liam G. McCoy, Timothy Miller, Amy Moreno, Nikolaj Munch, David Restrepo, Guergana Savova, Renato Umeton, Judy Wawira Gichoya, Gary S. Collins, Karel G. M. Moons, Leo A. Celi
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A generalist medical language model for disease diagnosis assistance Nat. Med. (IF 58.7) Pub Date : 2025-01-08 Xiaohong Liu, Hao Liu, Guoxing Yang, Zeyu Jiang, Shuguang Cui, Zhaoze Zhang, Huan Wang, Liyuan Tao, Yongchang Sun, Zhu Song, Tianpei Hong, Jin Yang, Tianrun Gao, Jiangjiang Zhang, Xiaohu Li, Jing Zhang, Ye Sang, Zhao Yang, Kanmin Xue, Song Wu, Ping Zhang, Jian Yang, Chunli Song, Guangyu Wang
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Toward expert-level medical question answering with large language models Nat. Med. (IF 58.7) Pub Date : 2025-01-08 Karan Singhal, Tao Tu, Juraj Gottweis, Rory Sayres, Ellery Wulczyn, Mohamed Amin, Le Hou, Kevin Clark, Stephen R. Pfohl, Heather Cole-Lewis, Darlene Neal, Qazi Mamunur Rashid, Mike Schaekermann, Amy Wang, Dev Dash, Jonathan H. Chen, Nigam H. Shah, Sami Lachgar, Philip Andrew Mansfield, Sushant Prakash, Bradley Green, Ewa Dominowska, Blaise Agüera y Arcas, Nenad Tomašev, Yun Liu, Renee Wong, Christopher
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Medical large language models are vulnerable to data-poisoning attacks Nat. Med. (IF 58.7) Pub Date : 2025-01-08 Daniel Alexander Alber, Zihao Yang, Anton Alyakin, Eunice Yang, Sumedha Rai, Aly A. Valliani, Jeff Zhang, Gabriel R. Rosenbaum, Ashley K. Amend-Thomas, David B. Kurland, Caroline M. Kremer, Alexander Eremiev, Bruck Negash, Daniel D. Wiggan, Michelle A. Nakatsuka, Karl L. Sangwon, Sean N. Neifert, Hammad A. Khan, Akshay Vinod Save, Adhith Palla, Eric A. Grin, Monika Hedman, Mustafa Nasir-Moin, Xujin
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Angiogenic factors versus fetomaternal Doppler for fetal growth restriction at term: an open-label, randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-01-07 Pablo Garcia-Manau, Erika Bonacina, Raquel Martin-Alonso, Lourdes Martin, Ana Palacios, Maria Luisa Sanchez-Camps, Cristina Lesmes, Ivan Hurtado, Esther Perez, Albert Tubau, Patricia Ibañez, Marina Alcoz, Nuria Valiño, Elena Moreno, Carlota Borrero, Esperanza Garcia, Eva Lopez-Quesada, Sonia Diaz, Jose Roman Broullon, Mireia Teixidor, Carolina Chulilla, Roser Ferrer-Costa, Maria M. Gil, Monica Lopez
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Nationwide real-world implementation of AI for cancer detection in population-based mammography screening Nat. Med. (IF 58.7) Pub Date : 2025-01-07 Nora Eisemann, Stefan Bunk, Trasias Mukama, Hannah Baltus, Susanne A. Elsner, Timo Gomille, Gerold Hecht, Sylvia Heywang-Köbrunner, Regine Rathmann, Katja Siegmann-Luz, Thilo Töllner, Toni Werner Vomweg, Christian Leibig, Alexander Katalinic
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Effects of early, late and self-selected time-restricted eating on visceral adipose tissue and cardiometabolic health in participants with overweight or obesity: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-01-07 Manuel Dote-Montero, Antonio Clavero-Jimeno, Elisa Merchán-Ramírez, Maddi Oses, Jon Echarte, Alba Camacho-Cardenosa, Mara Concepción, Francisco J. Amaro-Gahete, Juan M. A. Alcántara, Alejandro López-Vázquez, Rocío Cupeiro, Jairo H. Migueles, Alejandro De-la-O, Patricia V. García Pérez, Victoria Contreras-Bolivar, Araceli Muñoz-Garach, Ana Zugasti, Estrella Petrina, Natalia Alvarez de Eulate, Elena
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Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2025-01-07 Nicholas A. Vitanza, Rebecca Ronsley, Michelle Choe, Kristy Seidel, Wenjun Huang, Stephanie D. Rawlings-Rhea, Madison Beam, Leonel Steinmetzer, Ashley L. Wilson, Christopher Brown, Adam Beebe, Catherine Lindgren, Joshua A. Gustafson, Amy Wein, Susan Holtzclaw, Corrine Hoeppner, Hannah E. Goldstein, Samuel R. Browd, Jason S. Hauptman, Amy Lee, Jeffrey G. Ojemann, Erin E. Crotty, Sarah E. S. Leary, Francisco
更新日期：2025-01-26
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