Polycystic ovary syndrome (PCOS) is a common endocrine disorder that can lead to insulin resistance (IR) and dysregulation of glucose metabolism, resulting in an imbalance in the endometrial environment, which is unfavorable for embryo implantation of PCOS. This study aims to investigate whether nicotinamide mononucleotide (NMN) improves the stability of the endometrium in a rat model of PCOS and identifies whether it is related to reduce IR and increase glycolysis levels and its potential signaling pathway.

中文翻译：

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烟酰胺单核苷酸通过降低胰岛素抵抗和调节溶脂途径来改善多囊卵巢综合征大鼠模型的子宫内膜稳态


多囊卵巢综合征 （PCOS） 是一种常见的内分泌疾病，可导致胰岛素抵抗 （IR） 和葡萄糖代谢失调，导致子宫内膜环境失衡，不利于 PCOS 的胚胎植入。本研究旨在探讨烟酰胺单核苷酸 （NMN） 是否能提高 PCOS 大鼠模型中子宫内膜的稳定性，并确定它是否与降低 IR 和增加糖酵解水平及其潜在的信号通路有关。