My term as Editor-in-Chief for Organic Process Research & Development comes to an end in December 2024. I had the great honor to take over this role from Trevor Laird 10 years ago. Trevor had started the journal almost 20 years before and brought it into the family of American Chemical Society journals. The process chemistry community should be grateful to Trevor for having realized the need for a

Page 7820. The Strategic Leading Science and Technology Project of Chinese Academy of Sciences grant was incorrectly referenced as E4JD250301; the correct number is XDC0120102. The full correct Acknowledgment is in this Correction. This study was supported by the Strategic Leading Science and Technology Project of Chinese Academy of Sciences (grant no. XDC0120102), National Key Research and Development

A novel palladium-catalyzed domino radical cyclization and C-H activation/decarboxylation of 1,7-enynes with o-bromobenzoic acids and perfluoroalkyl iodides has been developed for the expedite construction of fused perfluoroalkyl-containing quinolin-2(1H)-one scaffolds. This method provides a facile synthesis of fused quinolin-2(1H)-one derivatives containing perfluoroalkyl unit in high yields. Notably

A concise total synthesis of natural prenylacridone alkaloids, N-methylcycloatalaphylline A, N-methylbuxifoliadine D, buxifoliadine D, oriciacridone E, glycocitrine II, norglycocitrine II, 3-O-methoxyglycocitrine II and new series of their non-natural analogues with diverse functionalities is achieved. Antibacterial assays of these alkaloids revealed that difluoro glycocitrine II derivative exhibits

Concealed non-Kekulé (CNK) nanographenes have recently gained attention as promising non-Kekulé model systems due to their distinctive antiferromagnetic electronic spins, which offer potential applications in spintronics and quantum information science. However, synthesizing CNK nanographenes in solution remains a significant challenge because of their strong biradical character and high reactivity

A novel solvent-dependent fluorescent probe P5T based onapillar[5]arene containing a thiosemicarbazone unit has been synthesized. This probe serves as a dual selective fluorescent probe, which can selectively detect Cu2+ and Hg2+ ions in mixed solvent systems of acetonitrile (AN) and dimethyl sulfoxide (DMSO) with water. A significant fluorescence enhancement was observed following adding Cu2+ to the

A mechanochemical radical direct C(sp2)-H trifluoromethylation of enamide derivatives was developed using Togni II reagent. Under a mechanochemical compression, application of 0.5 to 1.0 equivalent of piezoelectric materials enabled the solid-state formation of the key CF3 radical intermediate under mild and sustainable conditions. Catalytic amount of piezoelectric material proved to be just as efficient

Metal-catalyzed reductive coupling reactions between alkenes and alkynes are a long-standing tradition as a way to create complex unsaturated building blocks of value in organic synthesis ventures. Here, we review the general synthetic approaches realized under Co-catalysis utilizing chemical reductants, albeit with some limitations in scope and user-friendliness. A more recent advancement shows that

Herein, we report a novel palladium-catalyzed dearomative Heck/[4 + 3] decarboxylative cyclization of C2-tethered indoles with α-oxocarboxylic acids via C−H activation. In this reaction, dearomatization of C2-tethered indoles occurs via a Heck reaction pathway, leading to the formation of the alkyl-Pd(II) species. Subsequently, this species undergoes C−H activation, rather than the typical nucleophilic

Access to relatively high energy azetidines in enantioenriched form via a function- and diversity-oriented approach is highly desired in the field of drug-discovery. Although the demands for α-trifluoromethyl azetidines with great biological potential exist, effective strategies for catalytic asymmetric synthesis of these chemical entities with structural diversity remain elusive. To conquer this frontier

Bipolarsterols A−H (1−8), eight undescribed steroids were isolated from Bipolaris oryzae, along with nine known congeners. Their structures and absolute configurations were elucidated by comprehensive spectroscopic techniques, NMR and ECD calculations. Compound 1 presents the first example of a 19(l0→5)-abeo-7(8→9)-abeo-ergostane, featuring an unusual spiro[4.5]decan-6-one system, and compound 2 is

α-Chiral sulfonates have remained largely uncharted territory, primarily due to the intrinsic difficulties associated with achieving stereocontrol. In this study, we present an innovative three-component palladium-catalyzed asymmetric Tsuji-Trost sulfonylation protocol, which introduces a novel strategy for the synthesis of enantiomerically enriched α-chiral sulfonates, utilizing S(VI) complexes as

For 1,2,11-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline (5), the correct 1H and 13C NMR data presented below should be considered instead of those presented in the original paper. In addition, for compound 5, the correct 1H NMR spectrum presented in the revised Supporting Information should be considered instead of that presented in the original Supporting Information. 1H NMR (300