ScopeThe study assesses the metabolic impact of dietary whey proteins across generations.Method and resultsVirgin females are fed 20% energy whey proteins with 70% energy carbohydrates, which reduces body weight gain and visceral adipose compared to controls fed dietary casein. In contrast, the males are unresponsive. The effect is accentuated in reproductive females that also have reduced plasma levels of glucose. The responsive females have increased cecal levels of pyruvic and lactic acid, suggesting a greater catabolism of carbohydrates in the gut. While the male and female offspring born to mothers on whey proteins continue to reduce body weight gain, the female offspring further decreases the visceral and subcutaneous tissues and increases the gut capacity to breakdown dietary carbohydrates and proteins, whereas the male offspring are able to only decrease the visceral and increase protein catabolism in the gut. The ileum of male mice responded by reducing the gene expression for fibroblast growth factor 15 and increasing the expression of chymotrypsinogen B1.ConclusionThe effect of whey proteins on growth can be passed from the mother to the offspring without a sex preference, whereas the transmission of gut activity and adiposity are dependent on the sex of the offspring.

中文翻译：

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膳食乳清蛋白的性别依赖性和独立性影响从母亲传递给后代


范围该研究评估了膳食乳清蛋白对各代人的代谢影响。方法和结果处女女性喂食 20% 能量乳清蛋白和 70% 能量碳水化合物，与喂食膳食酪蛋白的对照组相比，这减少了体重增加和内脏脂肪。相比之下，雄性没有反应。这种影响在血浆葡萄糖水平也降低的生殖雌性中更加明显。反应灵敏的雌性蝶的盲肠丙酮酸和乳酸水平升高，表明肠道中碳水化合物的分解代谢更大。虽然使用乳清蛋白的母亲所生的雄性和雌性后代继续减少体重增加，但雌性后代进一步减少内脏和皮下组织，增加肠道分解膳食碳水化合物和蛋白质的能力，而雄性后代只能减少肠道中的内脏并增加蛋白质分解代谢。雄性小鼠的回肠通过降低成纤维细胞生长因子 15 的基因表达和增加胰凝乳蛋白酶原 B1 的表达来做出反应。结论乳清蛋白对生长的影响可以在没有性别偏好的情况下从母亲传递给后代，而肠道活动和肥胖的传递取决于后代的性别。