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New Series of 3-Pyridyl-1,3-Thiazoles: In Vitro and In Vivo Anti-Trypanosomatidae Profile, in vitro and in silico Mechanism of Action approach Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-20 Vanessa Gouveia de Melo Silva, Lucas Manoel da Silva Sousa, Expedito Lopes Fernandes Junior, Graziella Leite Brondani, Isabeli Maria de Albuquerque Oliveira, Danilo Cesar Galindo Bedor, Isabella Barbosa Pereira Lopes, Fabio André Brayner, Luiz Carlos Alves, Marton Kaique de Andrade Cavalcante, Daniele Santana de Souza Oliveira, Maria Carolina Accioly Brelaz-de-Castro, Policarpo Ademar Sales Junior
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Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Godwin A. Dziwornu, Henrietta Dede Attram, Cécile Haberli, Keabetswe Masike, Mathew Njoroge, Jennifer Keiser
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Discovery and optimization of 1,2,4-triazole derivatives as novel ferroptosis inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Jiawei Zhang, Fang Lin, Yijie Xiao, Si-Yu Cen, Bi-Wen Wan, Xuan Li, Yahui Zhao, Yi He, Hai-Xin Yuan, Shenyou Nie
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Synthetic Approaches and Clinical Applications of Representative HDAC Inhibitors for Cancer Therapy: A Review Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Zhengming Lv, Tianyi Ji, Jie Liu, Xu Sun, Huimin Liang
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Synthesis and Clinical Application of New Drugs Approved by NMPA in 2023 Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Lijuan Xie, Yingying Wang, Kunyu Wang, Wanying Chen, Fuwei Yang
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Advances in Selective c-MET Kinase Inhibitors: Application of Fused [5,6]-Bicyclic Nitrogen-Containing Cores for Anticancer Drug Design Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Mehdi Valipour, Zahra Zakeri khatir, Adileh Ayati, Asieh Hosseini, Mohammad Sheibani, Hamid Irannejad
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From Challenges to Solutions: A Review of Fourth-Generation EGFR Tyrosine Kinase Inhibitors to Overcome the C797S Triple Mutation in Non-Small Cell Lung Cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-19 Iqrar Ahmad, Harun M. Patel
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Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Linghao Hu, Hesong Xu, Ye Xu, Haowen Chen, Hanrui Jiang, Dounan Xu, Huimin Zhang, Cheng Luo, Shijie Chen, Mingliang Wang
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Clinically approved representative small-molecule drugs for cardiopathy therapy Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-16 Shaowei Ma, Min Jiang, Xiao Wang, Bin Li
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Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-16 Jung-Chun Chu, Keng-Chang Tsai, Ting-Yu Wang, Tzu-Yin Chen, Ju-Ying Tsai, Tien Lee, Mei-Hsiang Lin, Yves S.Y. Hsieh, Chin-Chung Wu, Wei-Jan Huang
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Discovery of novel XPO1 PROTAC degraders for the treatment of acute myeloid leukemia Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Guangyong Chen, Zhuo Chen, Huimin Liu, Chen Meng, Kai Wang, Haibin Lu, Fuwei Yang
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Dihydrofolate reductase inhibitory potential of 1H-indole-based-meldrum linked 1H-1,2,3-triazoles as new anticancer derivatives: In-vitro and in-silico studies Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Satya Kumar Avula, Saeed Ullah, Amirhossein Ebrahimi, Ali Rostami, Sobia Ahsan Halim, Ajmal Khan, Muhammad U. Anwar, Simon Gibbons, René Csuk, Ahmed Al-Harrasi
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Structurally diverse chromane meroterpenoids from Rhododendron capitatum with multifunctional neuroprotective effects Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-18 Ye-Fan Shi, Yue-Tong Zhu, Zi-Han Zhang, Meng-Song Chen, Song Gao, Qiang Zhang, Chun-Huan Li
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Novel Steroidal β-Carboline Derivatives as Promising Antibacterial Candidates against Methicillin-Resistant Staphylococcus aureus Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-18 Haibo Huo, Wenjia Dan, Libo Qin, Jiaxue Bo, Xiaonan Zhang, Chaofu Yang, Bianxia Bai, Jiahong Ren, Baojun Shi, Jian Li
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Unravelling the potential of natural chelating agents in the control of Staphylococcus aureus and Pseudomonas aeruginosa biofilms Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Miguel M. Leitão, Ariana S.C. Gonçalves, Joana Moreira, Carlos Fernandes, Fernanda Borges, Manuel Simões, Anabela Borges
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Discovery of pyridine-based derivatives as FLT3 inhibitors for the treatment of acute myeloid leukemia Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-16 Beijing Chen, Zhongyuan Wang, Qi Chen, Ying Zhang, Shengfei Wu, Yu Zhang, Aihong Li, Weiwei Ouyang, Lijie Sima, Xiaoxu Li, Dongsheng Zhao, Bilan Luo, Jianta Wang, Lei Tang, Xiaoming Su, Weike Liao
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Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Simona Sestito, Italo Cirone, Simona Sagona, Massimiliano Runfola, Lorenzo Raffellini, Veronica La Rocca, Valentina Citi, Alma Martelli, Simona Daniele, Michele Lai, Vincenzo Calderone, Claudia Martini, Clementina Manera, Simona Rapposelli
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Orvinol-based opioid receptor antagonist fluorinated at C(20)-pharmacophore Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-18 A.A. Ambartsumyan, I.V. Belozertseva, O.А. Dravolina, E.E. Zvartau, I.V. Sandulenko, M.V. Zelentsova, A.S. Peregudov, S.K. Moiseev
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Synthesis and structural modification of the natural product Ivesinol to discover novel autophagy activators Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Zhi-Peng Wang, Wenxin You, Jie Peng, Biao Xu, Xiaohong Yang, Wanyan Tang, Yun He, Aimin Yang, Chao Yu, Weiqi Nian
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Correction of aberrant splicing of ELP1 pre-mRNA by kinetin derivatives – a structure activity relationship study Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Barbara Maková, Václav Mik, Barbora Lišková, Lenka Drašarová, Martina Medvedíková, Alena Hořínková, Petr Vojta, Marek Zatloukal, Lucie Plíhalová, Martin Hönig, Karel Doležal, Kristýna Forejt, Tomáš Oždian, Marián Hajdúch, Miroslav Strnad, Jiří Voller
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The potential of MAO inhibitors as chemotherapeutics in cancer: A literature survey Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Sabina Sblano, Angelina Boccarelli, Caterina Deruvo, Gabriella La Spada, Modesto de Candia, Rosa Purgatorio, Cosimo Damiano Altomare, Marco Catto
Drug resistance in cancer is determined by genetic mutations and adaptations of tumor cells to drug treatments, raising a challenge in the treatment of cancer. Factors such as prolonged drug exposure, genetic variability among patients, and tumor heterogeneity have been established as contributors to rising incidence of drug resistance, prompting ongoing research into alternative therapies and combination
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Corrigendum to “Design, synthesis, and evaluation of novel pleuromutilin aryl acrylate derivatives as promising broad-spectrum antibiotics especially for combatting multi-drug resistant gram-negative bacteria” [Eur. J. Med. Chem. 259 (2023) 115653] Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-17 Min Li, Jialin Li, Jingyi Li, Jie Zhang, Yuqing Zhao, Wenying Li, Yunfei Zhang, Jinrong Hu, Xiaolin Xie, Dezhu Zhang, Han Li, Qianqian Zhao, Hong Gao, Chengyuan Liang
The authors regret that “Fig. 13. Observation of main organ tissue sections of mice with systemic infection of MRSA treated with different doses of 5g and valnemulin, the scale bar represents 100 μm.” was incorrect in the original manuscript. The figure has now been updated with the correct version. This error occurred during the image assembly process but does not affect the experimental results,
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A novel cyanine photosensitizer for sequential dual-site GSH depletion and ROS-potentiated cancer photodynamic therapy Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-12 Li Chen, Jun Yang, Feijing Su, Zihang Liu, Shuai Huang, Jifa Zhang, Jinqi Li, Wuyu Mao
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Discovery of the First Examples of Right Open Reading Frame Kinase 2 (RIOK2) Molecular Glue Degraders Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Haowen Ma, Cong Liu, Zihao Li, Qiuchun Yu, Huilan Xiong, Chaomin Huang, Li Tan, Min Zhan, Zhang Zhang, Qian Cai
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Chemical Dissection of Selective Myeloid Leukemia-1 Inhibitors: How They Were Found and Evolved Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Luyao Wang, Yuxiang Chen, Maoqian Zhang, Jin Liu, Haozhe Li, Menghui Liu, Shuyun Wu, Yongmin Zhang, Wei Li, Bo Wang
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Structure-based Development of N-Arylindole Derivatives as Pks13 Inhibitors against Mycobacterium Tuberculosis Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-15 Xuan Zhang, Shichun Lun, Yu-Xin Li, Wei Zhang, Ruo-Yi Zhou, Ting Liu, Fan Yang, Jie Tang, , Li-Fang Yu
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Advanced AI and ML frameworks for Transforming Drug Discovery and Optimization: With Innovative insights in Polypharmacology, Drug Repurposing, Combination Therapy and Nanomedicine. Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-13 Subiya Ambreen, Mohammad Umar, Aaisha Noor, Himangini Jain, Ruhi Ali
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Design and synthesis of novel 3,7-dihydro-1H-purine-2,6-diones as DPP-4 inhibitors: An in silico, in vitro and in vivo approach Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-12 Priya Bisht, Arka Bhattacharya, Anubroto Pal, Rajveer Singh, Sant Kumar Verma
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Matrix metalloproteinase-12 (MMP-12) and its inhibitors: A mini-review Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-12 Jigme Sangay Dorjay Tamang, Suvankar Banerjee, Sandip Kumar Baidya, Sanjib Das, Balaram Ghosh, Tarun Jha, Nilanjan Adhikari
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Designing novel Au(III) complexes based on the structure of diazepam: Achieving a multiaction mechanism against glioma Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-13 Yanping Li, Haoran Liu, Ronghao Fang, Jiamin Jin, Feng Yang, Jian Chen, Juzheng Zhang
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Impact of natural compounds on peroxisome proliferator-activated receptor: Molecular effects and its importance as a novel therapeutic target for neurological disorders Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-12 Zhe Zhu, Yadi Guan, Songlan Gao, Feng Guo, Dong Liu, Honglei Zhang
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Achieving theranostic probes targeting BRD3/BRD4 for imaging and therapy of tumor Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-12 Yuqi Gao, Qiao Liu, Cong Song, Shubin Song, Chengsen Tian, Jianjun Li, Wenjie Liu, Mingyu Cheng, Sitao Zhang, Xu Wang, Chengcai Xia, Tingting Liu
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Advancing Mitochondrial Therapeutics: Synthesis and Pharmacological Evaluation of Pyrazole-Based Inhibitors Targeting the Mitochondrial Pyruvate Carrier Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-11 Lingaiah Maram, Jessica M. Michael, Henry Politte, Vaishnavi S. Srirama, Aymen Hadji, Mohammad Habibi, Meredith O. Kelly, Rita T. Brookheart, Brian N. Finck, Lamees Hegazy, Kyle S. McCommis, Bahaa Elgendy
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Hydroxyl-based acid-hypersensitive acetal ester bond: Design, synthesis and the application potential in nanodrugs Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-11 Chuanqi Wang, Hong Xu, Ying Chen, Xiao Li, Hongyu Chen, Jianan Liu, Jirui Yang, Yuening Cao, Mengru Li, Jianli Ma, Bo Ren, Tingting Zhang, Xiujun Cao, Feiyan Tao, Jun Lu
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Marine actinomycetes-derived angucyclines and angucyclinones with biosynthesis and activity--past 10 years (2014–2023) Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-11 Xiao Xu, Xiaofei Huang, Wenhua Xu
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Corrigendum to “Antibacterial and antifungal pyrazoles based on different construction strategies” [Euro. J. Med. Chem. 282 (2025) 117081] Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-10 Muneeb Ur Rehman, Fang He, Xi Shu, Ju Guo, Ziwei Liu, Shuang Cao, Sihui Long
The authors regret: As researchers committed to advancing the field of medicinal chemistry, we hold ourselves to the highest standards of accuracy and rigor. We recognize the importance of delivering research that is both reliable and inspiring to our peers. In line with this commitment, we wish to ensure that our article does not leave any ambiguity or incorrect impressions on its readers.
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Combined usage of ligand- and structure-based virtual screening in the artificial intelligence era Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-10 Jingyi Dai, Ziyi Zhou, Yanru Zhao, Fanjing Kong, Zhenwei Zhai, Zhishan Zhu, Jie Cai, Sha Huang, Ying Xu, Tao Sun
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Design, synthesis, and evaluation of novel benzofuran and pyrazole-based derivatives as dual AChE/BuChE inhibitors with antioxidant properties for Alzheimer's disease management Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-10 Mahmoud S. Elkotamy, Mohamed K. Elgohary, Mahmoud Abdelrahman Alkabbani, Mohamed M. Hefina, Haytham O. Tawfik, Mohamed Fares, Wagdy M. Eldehna, Hatem A. Abdel-Aziz
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Design, synthesis, and biological evaluation of steroidal indole derivatives as membrane-targeting antibacterial candidates Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-10 Haibo Huo, Wenjia Dan, Min Li, Yanbin Chen, Chaofu Yang, Lintao Wu, Baojun Shi, Jian Li
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Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-10 Anna Kazakova, Ivo Frydrych, Nikola Jakubcová, Jan Pokorný, Barbora Lišková, Soňa Gurská, Renata Buriánová, Adam Přibylka, Petr Džubák, Marián Hajdúch, Milan Urban
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Prodrugging fungicidal amphotericin B significantly decreases its toxic effects Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-09 Ondřej Štěpánek, Marie Parigger, Eliška Procházková, Adéla Čmoková, Miroslav Kolařík, Helena Dračínská, Věra Černá, Květa Kalíková, Valéria Grobárová, Jan Černý, Jakob Scheler, Gottfried Schweiger, Ulrike Binder, Ondřej Baszczyňski
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Catalytic Lysine745 targeting strategy in fourth-generation EGFR tyrosine kinase inhibitors to address C797S mutation resistance Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-09 Bhatu R. Patil, Harun M. Patel
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Discovery of 22(S)-23-phenyl-24-norchol-5-en-3β,22-diol (PFM046) as the first-in-class, steroidal, non-sulfated Liver X Receptor antagonist with anticancer activity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-09 Lorenzo Pontini, Tommaso Angelini, Pietro Palazzoli, Daniela Maggioni, Gianluca Giorgi, Laura Raccosta, Giuseppe Damiano, Valerio Mammoli, Niccolò Fontana, Vincenzo Russo, Maura Marinozzi
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Discovery, synthesis, and antibacterial activity of novel myrtucommulone analogs as inhibitors of DNA gyrase and topoisomerase IV Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-08 Hao Yang, Jian Li, Bo-Lin Wang, Xin-Ya Yang, Yu Zhang
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Targeting ferroptosis offers therapy choice in sepsis-associated acute lung injury Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-08 Yu Wang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang
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Design, synthesis and biological evaluation of novel diaryl-substituted fused nitrogen heterocycles as tubulin polymerization inhibitors to overcome multidrug resistance in vitro and in vivo Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-08 Fuhao Jiang, Min Yu, Yang Wang
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Navigating cancer therapy: Harnessing the power of peptide-drug conjugates as precision delivery vehicles Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-07 Bulbul Sagar, Sarthak Gupta, Sarvesh Kumar Verma, Y. Veera Manohara Reddy, Shefali Shukla
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Synthesis of novel deuterated EGFR/ALK dual-target inhibitors and their activity against non-small cell lung cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-07 Haoran Nie, Shuai Zhang, Lihan Wang, Mengxuan Wang, Jiaqi Qiu, Fangyi Jia, Xingshu Li, Geng Tian, Baijiao An
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Hypoxia-selective prodrug restrains tumor cells through triggering mitophagy and inducing apoptosis Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-07 Fangjie Wang, Lairong Song, Qianqian Xu, Ang Jia, Xiangwei Meng, Hongfei Jiang, Renshuai Zhang
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The novel β-hairpin antimicrobial peptide D-G(RF)3 demonstrates exceptional antibacterial efficacy Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-07 Beibei Li, Yao Liu, Pengyi Yan, Xu Ouyang, Zufang Ba, Yu Wang, Tingting Yang, Zhongwei Yu, Bingqian Ren, Chao Zhong, Hui Liu, Yun Zhang, Sanhu Gou, Jingman Ni
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Design, synthesis, and antitumor evaluation of quinazoline-4-tetrahydroquinoline chemotypes as novel tubulin polymerization inhibitors targeting the colchicine site Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-06 Qinhuai Lai, Zhijia Wang, Chengyong Wu, Ruofei Zhang, Leyan Li, Yiran Tao, Dan Mo, Jifa Zhang, Lantu Gou, Yuxi Wang
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Structure-activity relationship studies and design of a PTPN22 inhibitor with enhanced isozyme selectivity and cellular efficacy Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-06 Brenson A. Jassim, Yunpeng Bai, Zihan Qu, Conrad J. Sander, Jianping Lin, Jinmin Miao, Zhong-Yin Zhang
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Synthesis and mechanistic studies of 4-aminoquinoline-Isatin molecular hybrids and Schiff's bases as promising antimicrobial agents Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-05 Mohd Shakir, Asghar Ali, Swati Lakshmi, Manika Garg, Haider Thaer Abdulhameed Almuqdadi, Iram Irfan, Mohan Kamthan, Mukesh C. Joshi, Saleem Javed, Diwan S. Rawat, Mohammad Abid
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Design and synthesis of novel benzoic acid derivatives as striatal-enriched protein tyrosine phosphatase (STEP) inhibitors with neuroprotective properties Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-05 Chunxue Jiang, Renshuai Liu, Yong Chang, Shiji Zhang, Xue Li, Zhongcheng Zhao, Mengyao Quan, Quande Wang, Hengxing Zhou, Xuben Hou, Hao Fang
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Small molecule inhibitors targeting PD-L1, CTLA4, VISTA, TIM-3, and LAG3 for cancer immunotherapy (2020–2024) Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-05 Binbin Cheng, Jinke Lv, Yao Xiao, Changshan Song, Jianjun Chen, Chuxiao Shao
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Design, synthesis and biological evaluation of novel β-carbolines as antitumor agents via targeting autophagy in colorectal cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-05 Jingsheng Ao, Chengyao Lai, Xiaofei Wu, Zhiyong Chen, Weijie Yang, Liqin Qiu, Xiangpan Li, Rihui Cao
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Design, synthesis and investigation of biological activity and mechanism of fluoroaryl-substituted derivatives at the FL118 position 7 Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-04 Wenchao Wang, Ruojiong Wang, Lianhao An, Lei Li, Haonan Xiong, Dan Li, Fangze Dong, Junrong Lei, Mengke Wang, Zhikun Yang, Hong Wang, Xiang Ling, Christos Fountzilas, Fengzhi Li, Qingyong Li
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Efficacy and molecular mechanisms of hesperidin in mitigating Alzheimer's disease: A systematic review Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-04 Xu Han, Yuting Zhang, Lijuan Zhang, Yanyan Zhuang, Yu Wang
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Gold(I) complexes bearing EGFR-inhibiting ligands as anti-HCC agents through dual targeting of EGFR and TrxR Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-04 Yawen Wang, Xiaoyan Ma, Xuejie Chen, Zhenfan Wen, Chunyang Bi, Zhongren Xu, Wukun Liu
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Structure-activity relationship study of novel evodiamine amino acid conjugates with potent anti-colorectal cancer efficacy Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-12-03 Shuting Chen, Xi Zhang, Hanxuan Mo, Ying Peng, Zhigang An, Junbo Wu, Xiuzhen Wei, Siyi Zhang, Yongxia Xiong, Weifan Jiang, Xue Peng, Linsheng Zhuo, Zhengwen Lei, Zhen Wang, Zecheng Hu