The prime function of the epithelium is to regulate the intestinal permeability; the latter is a quantitative parameter that refers to the measurement of the rate of passage of solutes through the epithelial monolayer. Function of epithelial monolayer depends on the expression of protein complexes known as tight junction proteins; whose function and expression can be disrupted under conditions of inflammation including irritable bowel disease (IBD), intestinal infections, and high‐fat diets, among others. This manuscript is focused to outline the effects of bovine milk protein derivatives on the intestinal permeability addressed mostly in animal models in which the intestinal barrier is disrupted. At present, the properties of bovine milk protein derivatives on intestinal permeability have been scarcely documented in humans, but evidence raised from clinical trials provides promising findings of potential application of colostrum to control of the intestinal permeability in critically ill patients, users of non‐steroid anti‐inflammatory drugs, like athletes and militia members.

中文翻译：

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深入了解牛奶中蛋白质衍生物的肠道通透性调节


上皮的主要功能是调节肠道通透性;后者是一个定量参数，指的是溶质通过上皮单层的速率的测量。上皮单层的功能取决于称为紧密连接蛋白的蛋白质复合物的表达;其功能和表达在炎症条件下可能会被破坏，包括肠易激病 （IBD）、肠道感染和高脂肪饮食等。本手稿的重点是概述牛奶蛋白衍生物对肠道通透性的影响，主要在肠道屏障被破坏的动物模型中解决。目前，牛奶蛋白衍生物对人类肠道通透性的特性几乎没有记录，但从临床试验中获得的证据提供了有希望的发现，即初乳可能应用于控制危重病人、非甾体抗炎药使用者，如运动员和民兵成员的肠道通透性。