In spectral absorption techniques, overlapping spectra cause distortion in absorption line heights, leading to inaccuracies in concentration measurements, which poses a significant challenge for measuring multi-component gases. In this paper, an innovative method that utilizes the displacement of the second harmonic (2f) peak to mitigate 2f height errors resulting from cross-interference is presented

Endotoxins or lipopolysaccharides (LPS) are potent inflammatory agents that pose serious health risks even at low concentrations, thus requiring sensitive and reliable detection methods. Current methods for endotoxin detection, primarily the Limulus Amebocyte Lysate (LAL) assay and Enzyme-linked Immunosorbent Assays (ELISA) are limited by complex procedures, prolonged assay time, and susceptibility

Chemical oxygen demand (COD) is a crucial parameter in assessing water quality. Due to the improved public awareness of environmental protection, the rapid, eco-friendly, and cost-effective methods for COD measurement are highly desired. This work proposes a new self-powered COD sensor (SPCS), based on a photocatalytic fuel cell composed of a FeN5 single-atom nanozymes (FeN5 SACs)/ITO cathode and a

In forensic investigations, the detection of Scopolamine, popularly known as Burundanga or Devil’s Breath, is of significant interest due to its potential involvement in cases of attempted murder or suicide. Currently, no efficient screening methods exist for Scopolamine detection in such forensic contexts. This study presents a novel method combining screen-printed graphite electrodes (SPGE) with

In this work, we constructed a manganese ion enhanced CRISPR fluorescence analysis platform based on magnetic separation technology and CRISPR/Cas12a system for the amplification-free detection of SARS-CoV-2 RNA. Firstly, nucleic acid functionalized magnetic beads and dual-function signal probes were used to identify conserved sequences of target RNA at the same time, and then the target was captured

The advancement of acetone gas sensors with superior responsiveness and selectivity has emerged as a paramount objective in current research endeavors. The current paper employs hydrothermal methodology to generate highly active porous material ZIF-8 on ZnO nanoflowers using porous rGO/ZnO (PGZ) composites as a matrix to form ZIF-8/PGZ composites for the detection of acetone gas. The ZIF-8/PGZ sensor

Monitoring biomarkers of mental stress, such as cortisol, in sweat is essential for understanding the body's endocrine response to stressful stimuli and assessing cognitive status. Nevertheless, the current stress monitoring method primarily depends on measuring heart rate variability, which lacks specificity and dramatically limits its applicability. This study introduces a wearable surface-enhanced

Microphysiological cartilage models provide excellent opportunities for modelling joint pathologies, including osteoarthritis. They are currently limited by their inability to facilitate real-time measurements of crucial disease progression markers. We integrated glucose and lactate biosensors in a human cartilage-on-a-chip system for in situ detection of disease-related shifts in chondrocyte metabolism

Electrochemiluminescence (ECL) has historically faced challenges such as limited ECL emitters and inadequate signal amplification, significantly hindering its practical applications. The development of novel ECL emitters is a crucial factor in advancing high-performance ECL biosensors. In this study, we propose an approach for compositing highly crystalline C3N4 nanoflowers (NFs) with C3N4 quantum

The structure and properties of polycrystalline Mg1-xCdx NdyFe2-yO4 (x = 0.0, 0.1, 0.3, 0.5, 0.7) (y = 0.02) are investigated through co-precipitation of oxalate from high-purity sulfate solutions. The samples are sintered at 500°C for five hours. The ferrite phase and cubic spinel structure are confirmed by TG-DTA, XRD, EDS, and Raman spectroscopy. As the Cd²⁺ content increases, the lattice constant

In this study, four sodium superionic conductors Na3Zr2-xZnxSi2PO12 (x=0, 0.1, 0.2, 0.3) were used as solid electrolytes for planar mixed-potential gas sensors (Zn0, Zn1, Zn2, and Zn3 sensors) to detect hydrogen sulfide (H2S) and sulfur dioxide (SO2). The total conductivity of the Na3Zr2-xZnxSi2PO12 electrolyte first increased and then decreased with increasing Zn2+ doping. When doped with 0.2 mol

At present, surgical resection is the primary clinical treatment method for pancreatic cancer. Accurate assessment of resectability is crucial for effective treatment planning. This paper focuses on the detection of carbohydrate antigen 125 (CA125), the in vitro biomarker for determining the resectability of pancreatic cancer. We prepared a highly stable electrochemiluminescence (ECL) luminophore,

The toxicity of SO2 is well known, so real-time monitoring of SO2 concentration is critical. Monitoring SO2 in industrial flue gas requires specially designed sensors to adapt to the complex application environment. In this study, a YSZ-based impedancemetric SO2 sensor was proposed and tested using non-stoichiometric LaxCuO4-δ (x=1.7, 2, 2.3) sensing electrode (SE) prepared by impregnation method.

The sensitive detection of molecular biomarkers has critical significance for early disease diagnoses and treatments. And, monitoring sarcosine levels in urine has increasing become new potential method for prostate cancer diagnosis. However, current techniques for sarcosine detection suffer simplicity, sensitivity, and specificity limitations. In this study, we introduce a novel enzyme-free, cascaded

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This study focuses on the precise in situ online detection of moisture content in paper utilizing a tapered optical fiber evanescent wave sensor made from a polyvinyl alcohol/diatomite moisture-sensitive material and plastic optical fibers. We developed a theoretical model to detect the moisture content in paper based on the principle that a moisture-sensitive material expands upon absorbing water

Electrochemical biosensors offer a cost-effective and noninvasive approach for continuously monitoring cortisol in complex bodily fluids like blood, sweat, or saliva. However, their high sensitivity makes them vulnerable to biological contamination when used with biological samples. In this study, an electrochemical sensor was developed using an antifouling molecularly-imprinted hydrogel that combines

Self-powered biosensors used for tumor biomarker detection exhibit the advantages of no external power supply and portability, but still face the challenges of low detection sensitivity and unstable power supply. In this study, enzyme biofuel cell (EBFC) technology is integrated with the sensor system to develop a self-powered sensor. The bioelectrode facilitates the conversion of chemical energy into

Cabin air pollution caused by microorganisms in automobile air conditioning systems can pose a significant health risk to drivers and passengers. Therefore, it is crucial to assess microbial contamination in vehicle air conditioning systems. This study introduces a novel approach utilizing a qualitative-quantitative two-stage hybrid algorithmic model for rapid detection of microbial populations in

Oxidative stress refers to an imbalance characterized by an excess of reactive oxygen species (ROS), which is closely linked to the pathogenesis of various diseases. Nanotools enabling single-cell sensing and degradation of ROS are envisioned to offer deeper insights into oxidative stress. Herein, we design a nanoreactor based on Cyt c encapsulated within zeolitic imidazolate framework-8 (ZIF-8) nanoparticles

Laccases, as multicopper oxidases, are essential for the analysis and degradation of phenolic pollutants. However, most laccase-like nanozymes reported to date feature copper as the active sites, and the exploration of copper-free laccase nanozymes remains limited. In this study, we have discovered that single-atom ruthenium (Ru) exhibits high laccase-like activity. The single-atom Ru mimics the active

An electrochemical aptasensor has been developed to realize the rapid and sensitive detection of Aflatoxin B1 (AFB1). Cobalt-carbon nanomaterial (Co-C) using ZIF-67 as the precursor was served as the sensing substrate. The ZIF-67-derived Co-C with good electrical conductivity and large specific surface could significantly increase the electroactive area and promote electron transfer on the sensing

Ferroptosis is highly associated with reactive oxygen species (ROS), especially the hydroxyl radical (•OH) that induces lipid peroxide accumulation, which may have significant effect on polarity changes, but with no clear evidence of the relationship. Therefore, it is vital and challenging to monitor polarity and •OH simultaneously for further exploration of the mechanisms of ferroptosis. Therefore

Cell membrane proteins are important components used to study cellular life processes and for clinical diagnostics. Currently, the signal of membrane protein imaging is limited to the pivot of the target, significantly limiting signal amplification efficiency and output, unlike the efficiency observed in solution systems. Inspired by the widespread recruitment phenomenon in natural life activities

Parkinson's disease (PD) is the second most common neurodegenerative disease, PD and its complications threatening life of millions people worldwide. Early diagnosis is essential but remains one major challenge for effective treatment of PD. Onset and progression of PD are often underlined by multiple biological factors, which aggravates the dilemma. Development of activatable probes is considered

The early rapid and ultrasensitive detection of pathogenic bacteria is crucial for preventing foodborne illnesses and addressing bacterial infections effectively. Herein, we have developed an ultrasensitive and rapid method for detecting Salmonella typhimurium based on specific phage tail spike protein-magnetic separation, dual signal amplification by four-in-one AuPt nanoparticles coated enzyme-antibiotic-inorganic

Metal oxide semiconductor (MOS)-based hydrogen (H2) sensor that can work at room or near room temperature has attracted an increasing concern owing to its potential application in hydrogen storage and utilization. Herein, a co-sensitization strategy by La doping and Pd decoration is proposed to realize the detection of H2 at near room temperature (50 °C) on In2O3 porous nanotubes (PNTs). The In2O3

In recent years, poly(ionic liquid)s (PILs) have attracted much attention for the application in humidity sensors. However, the ionic conductivity of PILs is inhibited in the low humidity range. In this work, discontinuous conductive template was prepared using a hydrophobic conductive polymer PEDOT:F, and PILs was prepared in situ on the conductive template (PFCT&PILs) to obtain a low humidity sensor

The rational construction of semiconductor heterojunctions with abundant active specific area and matched energy band alignment is vital to boosting photocurrent response in highly sensitive photoelectrochemical (PEC) sensors. Here, a molecularly imprinted PEC sensor is proposed based on a WO3/BiVO4 heterojunction using CAU-17, a Bi-based metal-organic framework (MOF), as a structural control agent