Lactate, a signaling molecule and energy source, crosses membranes through monocarboxylate transporters (MCTs). MCT1 and MCT4 are potential cancer drug targets due to their role in metabolic reprogramming of cancer cells. Stilbenes, plant secondary metabolites found in several food sources, have anticancer effects, though their mechanisms of action are not well understood. This study links the anticancer activity of natural stilbenes to tumor cell lactate metabolism.

中文翻译：

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天然二苯乙烯白皮杉醇对单羧酸转运蛋白介导的体外乳酸转运的抑制作用


乳酸是一种信号分子和能量来源，通过单羧酸转运蛋白 （MCT） 穿过膜。MCT1 和 MCT4 是潜在的癌症药物靶点，因为它们在癌细胞的代谢重编程中发挥作用。二苯乙烯是在多种食物来源中发现的植物次生代谢物，具有抗癌作用，尽管它们的作用机制尚不清楚。本研究将天然二苯乙烯的抗癌活性与肿瘤细胞乳酸代谢联系起来。