ScopeAt present, the incidence rate of ulcerative colitis (UC) continues to increase, causing a global burden. In addition, therapeutic drugs have great side effects. According to modern pharmacology, agarwood leaves have anti‐inflammatory, antibacterial, hypoglycemic, and lipid‐lowering effects. Therefore, this experiment on DSS induced colitis treatment of polyphenolic substances in agarwood leaves is feasible and in line with the current hot topic of using natural substances instead of drugs for treatment.Methods and resultsALP supplementation promotes the expression of tight junction proteins occludin and Zonula occludens protein 1 (ZO‐1) on colonic tissues, repairs the intestinal barrier, and relieves further colonic tissue damage. Besides, ALP effectively inhibits the activation of nuclear factor kappa‐B (NF‐кB) signaling pathway and reduces the release of proinflammatory cytokines. Moreover, ALP reverses the alteration of gut microbiota in the colitic mice by increasing the abundances of Parabacteroides, Chlamydia, and Lachnospiraceae, and decreasing the abundances of Bacteroides and Phocaeicola. Furthermore, the correlation analysis suggested that ALP can attenuate DSS‐induced UC, which is probably related to the alterations in the gut microbiota.ConclusionALP can ameliorate DSS‐induced UC by modulating gut microbiota, intestinal barrier function, and inflammatory responses.

中文翻译：

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沉香叶茶中富含酚类物质的提取物通过调节肠道屏障功能、肝脏炎症和肠道微生物群来缓解葡聚糖硫酸钠 （DSS） 诱导的溃疡性结肠炎


范围目前，溃疡性结肠炎 （UC） 的发病率持续增加，造成全球负担。此外，治疗药物具有很大的副作用。根据现代药理学，沉香叶具有抗炎、抗菌、降血糖和降脂作用。因此，这项 DSS 诱导沉香叶中多酚物质治疗结肠炎的实验是可行的，并且符合当前使用天然物质代替药物治疗的热门话题。方法和结果补充 ALP 促进结肠组织紧密连接蛋白 occludin 和 Zonula occludens 蛋白 1 （ZO-1） 的表达，修复肠道屏障，并进一步缓解结肠组织损伤。此外，ALP 有效抑制核因子 kappa-B （NF-кB） 信号通路的激活并减少促炎细胞因子的释放。此外，ALP 通过增加副拟杆菌属、衣原体和毛螺菌科的丰度，以及降低拟杆菌属和 Phocaecola 的丰度来逆转结肠炎小鼠肠道菌群的改变。此外，相关性分析表明，ALP 可以减轻 DSS 诱导的 UC，这可能与肠道菌群的改变有关。结论ALP 可通过调节肠道菌群、肠道屏障功能和炎症反应来改善 DSS 诱导的 UC。