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Next-generation patient models for colorectal cancer research Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-02
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High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-02 Ayano C. Kohlgruber, Mohammad H. Dezfulian, Brandon M. Sie, Charlotte I. Wang, Tomasz Kula, Uri Laserson, H. Benjamin Larman, Stephen J. Elledge
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Tracking-seq reveals the heterogeneity of off-target effects in CRISPR–Cas9-mediated genome editing Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-02 Ming Zhu, Runda Xu, Junsong Yuan, Jiacheng Wang, Xiaoyu Ren, Tingting Cong, Yaxian You, Anji Ju, Longchen Xu, Huimin Wang, Peiyuan Zheng, Huiying Tao, Chunhua Lin, Honghao Yu, Juanjuan Du, Xin Lin, Wei Xie, Yinqing Li, Xun Lan
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Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-02 L. Francisco Lorenzo-Martín, Nicolas Broguiere, Jakob Langer, Lucie Tillard, Mikhail Nikolaev, George Coukos, Krisztian Homicsko, Matthias P. Lutolf
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Cryptic enzymatic assembly of peptides armed with β-lactone warheads Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-01 Guangcai Xu, Daniele Torri, Sebastian Cuesta-Hoyos, Deepanjan Panda, Luke R. L. Yates, Rémi Zallot, Kehan Bian, Dongxu Jia, Andreea I. Iorgu, Colin Levy, Sarah A. Shepherd, Jason Micklefield
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Transition transferases prime bacterial capsule polymerization Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-01 Christa Litschko, Valerio Di Domenico, Julia Schulze, Sizhe Li, Olga G. Ovchinnikova, Thijs Voskuilen, Andrea Bethe, Javier O. Cifuente, Alberto Marina, Insa Budde, Tim A. Mast, Małgorzata Sulewska, Monika Berger, Falk F. R. Buettner, Todd L. Lowary, Chris Whitfield, Jeroen D. C. Codée, Mario Schubert, Marcelo E. Guerin, Timm Fiebig
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The chemical language of protein glycation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-28 Meghan S. Martin, Jeremiah W. Jacob-Dolan, Vo Tri Tin Pham, Nicole M. Sjoblom, Rebecca A. Scheck
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Potent and specific antibiotic combination therapy against Clostridioides difficile Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-28 Vasiliki T. Chioti, Kirklin L. McWhorter, Tamra C. Blue, Yuchen Li, Fei Xu, Philip D. Jeffrey, Katherine M. Davis, Mohammad R. Seyedsayamdost
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Proteins dance to the tune of light Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-27 Christopher S. Waters
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CRISPR screens of tumor-infiltrating NK cells identify genetic checkpoints for CAR-NK therapy Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-25
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Sulfoquinovosyl diacylglycerol is required for dimerisation of the Rhodobacter sphaeroides reaction centre-light harvesting 1 core complex Biochem. J. (IF 4.4) Pub Date : 2024-07-03 Martin, Elizabeth C., Bowie, Adam G.M., Wellfare Reid, Taylor, Neil Hunter, C., Hitchcock, Andrew, Swainsbury, David J.K.
The reaction centre-light harvesting 1 (RC-LH1) core complex is indispensable for anoxygenic photosynthesis. In the purple bacterium Rhodobacter (Rba.) sphaeroides RC-LH1 is produced both as a monomer, in which 14 LH1 subunits form a C-shaped antenna around 1 RC, and as a dimer, where 28 LH1 subunits form an S-shaped antenna surrounding 2 RCs. Alongside the five RC and LH1 subunits, an additional polypeptide
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Synthetic gene circuit evolution: Insights and opportunities at the mid-scale Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-25 Christopher Helenek, Rafał Krzysztoń, Julia Petreczky, Yiming Wan, Mariana Cabral, Damiano Coraci, Gábor Balázsi
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Identifying p53-independent apoptosis Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-24 Yiyun Song
The p53 protein is a key transcription factor responsible for inducing apoptosis in response to DNA damage, such as damage induced by chemotherapeutics. However, cells with an impaired p53 pathway can still undergo apoptosis, suggesting the existence of alternative p53-independent apoptosis pathways in these cells. Boon et al. have now identified such a pathway, in which ribosomes stall on the rare
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A direct hit Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-24 Grant Miura
Treating Gram-negative bacteria with antibiotics remains difficult due to the lack of a target that is specific for this population while sparing other innocuous groups. Broad spectrum antibiotics are known to affect gut microbiome diversity which can result in secondary Clostridioides difficile infections. The Lol system, which mediates lipoprotein transport between the inner and outer membranes in
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On the quest for mescaline Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-24 Francesco Zamberlan
Mescaline, a substituted phenethylamine protoalkaloid, is the primary hallucinogenic compound in psychedelic cacti such as Lophophora williamsii (commonly known as peyote). The mescaline biosynthetic pathway has been postulated for half a century; it entails hydroxylation and decarboxylation of l-tyrosine to dopamine through tyramine or l-3,4-dihydroxyphenylalanine (l-DOPA), followed by a series of
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Increasing access to biotech products for animal agriculture in Sub-Saharan Africa through partnerships Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-25 José de la Fuente, Christian Gortázar, Marinela Contreras, Frederick Kabi, Paul Kasaija, Swidiq Mugerwa, Justus Rutaisire
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In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-25 Lei Peng, Paul A. Renauer, Giacomo Sferruzza, Luojia Yang, Yongji Zou, Zhenghao Fang, Jonathan J. Park, Ryan D. Chow, Yueqi Zhang, Qianqian Lin, Meizhu Bai, Angelica Sanchez, Yongzhan Zhang, Stanley Z. Lam, Lupeng Ye, Sidi Chen
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C646 degrades Exportin-1 to modulate p300 chromatin occupancy and function Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-24 Yi Fan Chen, Atikur Rahman, Joel L. Sax, Matthew J. Atala Pleshinger, Ryan M. Friedrich, Drew J. Adams
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All roads lead to OSBP Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Po-Hsun Brian Chen, Jeremy M. Baskin
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Recording calcium concentrations Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Yuki Ito, Tetsuya Takano
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Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Nianzhe He, Laura Depta, Cecilia Rossetti, Lucie Caramelle, Marko Cigler, Hogan P. Bryce-Rogers, Marine Michon, Oliver Rafn Dan, Joseph Hoock, Julien Barbier, Daniel Gillet, Alison Forrester, Georg E. Winter, Luca Laraia
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Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Marko Cigler, Hana Imrichova, Fabian Frommelt, Lucie Caramelle, Laura Depta, Andrea Rukavina, Chrysanthi Kagiou, J. Thomas Hannich, Cristina Mayor-Ruiz, Giulio Superti-Furga, Sonja Sievers, Alison Forrester, Luca Laraia, Herbert Waldmann, Georg E. Winter
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The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Vinayak Agarwal, Andrew C. McShan
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Machine learning prediction of prime editing efficiency across diverse chromatin contexts Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-21 Nicolas Mathis, Ahmed Allam, András Tálas, Lucas Kissling, Elena Benvenuto, Lukas Schmidheini, Ruben Schep, Tanav Damodharan, Zsolt Balázs, Sharan Janjuha, Eleonora I. Ioannidi, Desirée Böck, Bas van Steensel, Michael Krauthammer, Gerald Schwank
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14-3-3ζ Suppresses RANKL Signaling by Destabilizing TRAF6 J. Biol. Chem. (IF 4.0) Pub Date : 2024-06-21 R. Ayyasamy, S. Fan, P. Czernik, B. Lecka-Czernik, S. Chattopadhyay, R. Chakravarti
Macrophages are essential regulators of inflammation and bone loss. RANKL, a pro-inflammatory cytokine, is responsible for macrophage differentiation to osteoclasts and bone loss. We recently showed that 14-3-3ζ-knockout () rats exhibit increased bone loss in the inflammatory arthritis model. 14-3-3ζ is a cytosolic adaptor protein that actively participates in many signaling transductions. However
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Rationally seeded computational protein design of ɑ-helical barrels Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-20 Katherine I. Albanese, Rokas Petrenas, Fabio Pirro, Elise A. Naudin, Ufuk Borucu, William M. Dawson, D. Arne Scott, Graham. J. Leggett, Orion D. Weiner, Thomas A. A. Oliver, Derek N. Woolfson
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Effects of the first successful lawsuit against a consumer neurotechnology company for violating brain data privacy Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-20 José M. Muñoz, José Ángel Marinaro, José Antonio Iglesias, Moisés Sánchez, Natalia Monti, Ciro Colombara, Guido Girardi
On 9 August 2023 the Supreme Court of Chile (SCC) ruled in favor of former senator Guido Girardi in a constitutional protection appeal filed against the neurotechnology company Emotiv1 for violating his rights to privacy and psychological integrity, which are enshrined in Article 19 of Chile’s constitution2. The authors of the present piece — the plaintiff, some of his lawyers and legal advisers, and
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Induced proximity in biology and therapeutics Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-20 The Cell Chemical Biology editorial team
No Abstract
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Meet the authors: Markella Konstantinidou and Michelle R. Arkin Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-20 Markella Konstantinidou, Michelle R. Arkin
In an interview with Dr. Ying Li, a scientific editor of Cell Chemical Biology, the authors of the Review titled “Molecular glues for protein-protein interactions: Progressing toward a new dream” share their perspectives on their field and life as scientists.
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Meet the authors: Lauren Kageler, Jonathan Perr, and Ryan A. Flynn Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-20 Lauren Kageler, Jonathan Perr, Ryan A. Flynn
In an interview with Dr. Mishtu Dey, editor-in-chief of Cell Chemical Biology, the authors of the review titled “Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology”—Lauren Kageler, Jonathan Perr, and Dr. Ryan A. Flynn—tell us more about their career paths and what excites them about science.
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The culinary chemist: Out of the lab and into the tent Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-20 Joshua P. Smalley
In this Stories piece, Josh Smalley, a postdoctoral research associate at the University of Leicester and finalist of The Great British Bake Off, discusses the parallels between chemistry and baking, revealing how he successfully combines the two.
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Application of induced proximity for therapeutic discovery Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-20 Angela Cacace, Danette Daniels, Fleur M. Ferguson, Cristina Mayor-Ruiz, Christina Woo
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Velcrin compounds activate the SLFN12 tRNase to induce tomoptosis Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-20 Heidi Greulich
Velcrins are molecular glues that induce complex formation between PDE3A and SLFN12. The PDE3A-SLFN12 complex activates the SLFN12 RNase, resulting in cleavage of the specific substrate, tRNA-Leu-TAA, global inhibition of translation, and death of cells expressing sufficient levels of both proteins. Here, unanswered questions about the mechanism of action and therapeutic promise of velcrin compounds
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Get your receptors in a knot with new Wnt signaling agonists Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-20 Lucie Wolf, Stephane Angers
Pharmacological modulation of the Wnt/β-catenin signaling pathway holds promises for both basic research and therapeutic applications. In this issue of Cell Chemical Biology, Kschonsak et al.1 engineered knotted peptides that promote Wnt signaling by targeting ZNRF3 and serve as pharmacological tools for studying Wnt biology and supporting organoid growth.
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A double whammy for KEAP1 Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-20 Jan Gerhartz, Radosław P. Nowak
In this issue of Cell Chemical Biology, Lu et al.1 report the discovery of a bivalent KEAP1 inhibitor (biKEAP1), which more rapidly activates NRF2 compared to previously reported monovalent KEAP1 inhibitors. biKEAP1suppresses acute inflammation in animal models.
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NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-20 Xiaotong Zhu, Ye Li, Haixia Liu, Yuetong Wang, Renhong Sun, Zhenzhou Jiang, Chun Hou, Xianyu Hou, Suming Huang, Huijuan Zhang, Haopeng Wang, Biao Jiang, Xiaobao Yang, Bin Xu, Gaofeng Fan
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Channeling kynurenine Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-19 Mollie I. Sweeney, David M. Tobin
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3-Hydroxykynurenine targets kainate receptors to promote defense against infection Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-19 Margarita Parada-Kusz, Anne E. Clatworthy, Emily R. Goering, Stephanie M. Blackwood, Jack Y. Shigeta, Eivgeni Mashin, Elizabeth J. Salm, Catherine Choi, Senya Combs, Jenny S. W. Lee, Carlos Rodriguez-Osorio, Clary Clish, Susumu Tomita, Deborah T. Hung
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Editor’s pick: Tenpoint Therapeutics Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-19
Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year. Tenpoint Therapeutics optimizes delivery and generation of stem-cell-derived retinal cells for vision repair.
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Tracking gene order provides a new perspective on intraspecific evolution in microbiotas Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-19
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Editor’s pick: Tome Biosciences Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-19
Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year. Tome Biosciences inserts large DNA sequences into precise genomic locations, overcoming limitations of base and prime editing.
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Strain tracking in complex microbiomes using synteny analysis reveals per-species modes of evolution Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-19 Hagay Enav, Inbal Paz, Ruth E. Ley
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Architecture of the RNF1 complex that drives biological nitrogen fixation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-18 Lin Zhang, Oliver Einsle
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Quantitative control of subcellular protein localization with a photochromic dimerizer Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-18 Takato Mashita, Toshiyuki Kowada, Hayashi Yamamoto, Satoshi Hamaguchi, Toshizo Sato, Toshitaka Matsui, Shin Mizukami
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Aflatoxin biosynthesis regulators AflR and AflS: DNA binding affinity, stoichiometry, and kinetics Biochem. J. (IF 4.4) Pub Date : 2024-06-19 Abbas, Asmaa, Prajapati, Ranjit K., Aalto-Setälä, Emil, Baykov, Alexander A., Malinen, Anssi M.
Aflatoxins (AFs), potent foodborne carcinogens produced by Aspergillus fungi, pose significant health risks worldwide and present challenges to food safety and productivity in the food chain. Novel strategies for disrupting AF production, cultivating resilient crops, and detecting contaminated food are urgently needed. Understanding the regulatory mechanisms of AF production is pivotal for targeted
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Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases Cell Chem. Bio. (IF 6.6) Pub Date : 2024-06-17 Lin Han, Augustus Pendleton, Adarsh Singh, Raymond Xu, Samantha A. Scott, Jaymee A. Palma, Peter Diebold, Kien P. Malarney, Ilana L. Brito, Pamela V. Chang
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Engineered yeast produces the plant-based vaccine adjuvant QS-21 Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17 Iris Marchal
Extracting pharmacological compounds from plants can be ecologically damaging and often results in low yields, which limits their broad use. For instance, the supply of the potent vaccine adjuvant QS-21 is dependent on laborious extraction from the bark of the Chilean soapbark tree. Writing in Nature, Liu et al. describe an alternative method to produce QS-21 and its derivatives at scale using engineered
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OpenFold provides insights into AlphaFold2’s learning behavior Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17 Iris Marchal
Despite the immense utility of AlphaFold2 in predicting protein structure, the official implementation excludes code for its training procedure and the associated required data. This makes it difficult to study the model’s learning behavior and to create variants that can perform new tasks. Writing in Nature Methods, AlQuraishi and colleagues now report OpenFold, a trainable and open-source implementation
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Honey without bees Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17
Honey has been a prized food since ancient times. A complex blend of sugars, mostly fructose and glucose, and small amounts of other sugars, proteins, amino acids, vitamins and minerals, honey is a $8.94 billion market, and its popularity continues to grow. But over the last decade, honeybees (Apis mellifera) have been hindered from making this natural product by disappearing grassland, herbicides
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A vaccine strategy for inducing broadly neutralizing antibodies against HIV Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17 Iris Marchal
An effective HIV vaccine must induce broadly neutralizing antibodies (bnAbs) that target the most conserved sites of the HIV envelope, a feat that has not yet been achieved in humans. Germline-targeting vaccine design holds promise by using immunogens to prime naive B cells for bnAb precursor activation and then boosting their maturation. A major challenge for this approach is that antibody–antigen
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First-in-class T cell engager approved for lung cancer Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17
Amgen’s T cell engager Imdelltra (tarlatamab) has gained FDA accelerated approval for an aggressive type of cell lung cancer that is notoriously difficult to treat. The bispecific antibody is designed to bind both delta-like ligand 3 (DLL3) on small cell lung cancer (SCLC) cells and CD3 on T cells. Pharma companies have long considered DDL3 a promising target in oncology because healthy cells express
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Forum: Anikeeva, Courtine and Bloch Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17
On this episode, Chief Editor Barbara Cheifet speaks with Polina Anikeeva from MIT, Grégoire Courtine from EPFL, and Jocelyn Bloch, a neurosurgeon at Lausanne University Hospital. These three leaders in the field of neurotechnologies discuss new devices that help us learn how our brain works, implantable brain–computer interfaces that are helping patients with neurological disorders walk again, and
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Biotech news from around the world Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17
The kingdom pledges $500 million to the Bill & Melinda Gates Foundation to help fight polio. The funding, which helps close the funding gap in the $4.8 billion budget for the Global Polio Eradication Initiative, will be spread out over five years and makes Saudi Arabia one of the biggest national donors, along with the United States. A pilot project by the government of New South Wales has produced
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Gene therapy restores hearing Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17
Regeneron Pharmaceuticals has released preliminary data from the first two patients treated with the investigational gene therapy DB-OTO. At the American Society for Gene and Cell Therapy (ASGCT) annual meeting in May, the company disclosed that, during the CHORD clinical trial, designed to evaluate safety and tolerability, the gene therapy improved hearing in two children with profound genetic deafness
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Cancer diagnostics Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17
Recent patents relating to systems and methods for cancer detection and diagnosis.
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Bird flu in wastewater Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17
The Centers for Disease Control and Prevention (CDC) is testing wastewater across the United States to track the spread of influenza virus, including the avian influenza A virus H5N1 outbreak. The CDC and its partners are sampling wastewater from 689 sites to detect influenza A virus by quantitative PCR. The surveillance and reporting system also includes monkeypox and SARS-CoV-2. Data from May 5–18
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B cells as drug factories Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17
Companies are engineering B cells to produce gene-encoded medicines, but clinical proof of concept is needed to convince the doubters that this platform can deliver.
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People Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17
Recent moves of note in and around the biotech and pharma industries.
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Barriers and enablers to the effective implementation of omics research in low- and middle-income countries Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17 Jacus S. Nacis, Patrick Kamande, Alemayehu Teklu Toni, Evans Mudibo, Robert Musyimi, Siam Popluechai, Trenton Dailey-Chwalibóg, Wieger Voskuijl, Genevieve Dable-Tupas, Abu Sadat Mohammad Sayeem Bin Shahid, Neil Andrew Bascos, Farzana Afroze, Mohammod Jobayer Chisti, Benson Singa, Moses Ngari, Caroline Tigoi, Gomezgani Mhango, Harry Freitag, Isabel Potani, John Mukisa, Amir Kirolos, Kuda Mutasa, Lionel
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The sufficiency of disclosure of medical artificial intelligence patents Nat. Biotechnol. (IF 33.1) Pub Date : 2024-06-17 Mateo Aboy, W. Nicholson Price, Seth Raker, Kathleen Liddell