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Acylated Anthocyanins From Black Carrots and Their Related Phenolic Acids Diminish Priming and Activation of the NLRP3 Inflammasome in THP-1 Monocytes
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-10-19 , DOI: 10.1002/mnfr.202400356 Inken Behrendt, Katharina Becker, Christof Björn Steingass, Ralf Schweiggert, Gabriela Michel, Elvira Friedrich, Daniela Grote, Zoe Martin, Hanna Pauline Dötzer, Mathias Fasshauer, Martin Speckmann, Sabine Kuntz
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-10-19 , DOI: 10.1002/mnfr.202400356 Inken Behrendt, Katharina Becker, Christof Björn Steingass, Ralf Schweiggert, Gabriela Michel, Elvira Friedrich, Daniela Grote, Zoe Martin, Hanna Pauline Dötzer, Mathias Fasshauer, Martin Speckmann, Sabine Kuntz
Excessive activation of the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome contributes to chronic inflammation. Thus, targeting NLRP3 inflammasome activation by anthocyanins may prevent inflammatory diseases. Therefore, the present study determines the influence of a black carrot extract (BCE) with high amounts of acylated anthocyanins and their related phenolic acids on the NLRP3 inflammasome.
中文翻译:
来自黑胡萝卜的酰化花青素及其相关的酚酸会减少 THP-1 单核细胞中 NLRP3 炎性小体的启动和激活
核苷酸结合寡聚结构域样受体 pyrin 结构域包含蛋白结构域的蛋白 3 (NLRP3) 炎性小体的过度激活会导致慢性炎症。因此,通过花青素靶向 NLRP3 炎性小体激活可以预防炎症性疾病。因此,本研究确定了含有大量酰化花青素及其相关酚酸的黑胡萝卜提取物 (BCE) 对 NLRP3 炎性小体的影响。
更新日期:2024-10-19
中文翻译:
来自黑胡萝卜的酰化花青素及其相关的酚酸会减少 THP-1 单核细胞中 NLRP3 炎性小体的启动和激活
核苷酸结合寡聚结构域样受体 pyrin 结构域包含蛋白结构域的蛋白 3 (NLRP3) 炎性小体的过度激活会导致慢性炎症。因此,通过花青素靶向 NLRP3 炎性小体激活可以预防炎症性疾病。因此,本研究确定了含有大量酰化花青素及其相关酚酸的黑胡萝卜提取物 (BCE) 对 NLRP3 炎性小体的影响。