ScopeType 2 diabetes mellitus (T2DM) is a metabolic disease with a major global public health effect. Rambutan peel polyphenols (RPPs) have been reported to exert hypoglycemic activity. However, few studies have been explored from the viewpoint of gut microbiota and its metabolites.Methods and resultsRPPs are administered by gavage to a mice model of T2DM established by using a high‐fat diet combined with streptozotocin. It finds that RPPs treatment alleviates hyperglycemia symptoms by improving glucolipid metabolism and liver function. Immunohistochemistry indicates that the antihyperglycemic effect of RPPs is regulated by the IRS‐1/PI3K/AKT/GSK3β signaling pathway. RPPs treatment remodels the structure of gut microbiota (Odoribacter, Lachnospiraceae_NK4A136_group, Lactobacillus, Turicibacter, Erysipelatoclostridium, and Tuzzerella) and enriches the metabolites (RPPs‐derived urolithins, short‐chain fatty acids, dehydrocholic acid, (+)‐catechin, dihydroberberine, pterostilbene, and artesunate) associated with diabetes regulation in T2DM mice. The effects of RPPs in ameliorating glycolipid metabolism disorders are correlated with differential gut microbiota and metabolites.ConclusionThe gut microbiota and its metabolites are key targets for the hypoglycemic effects of RPPs.

中文翻译：

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红毛丹 （Nephelium lappaceum L.） 的降糖作用通过调节肠道微生物群和代谢物来剥离 2 型糖尿病小鼠的多酚


范围2 型糖尿病 （T2DM） 是一种对全球公共卫生具有重大影响的代谢性疾病。据报道，红毛丹皮多酚 （RPP） 具有降血糖活性。然而，从肠道微生物群及其代谢物的角度探讨的研究很少。方法和结果RPPs通过管饲法施用到通过使用高脂肪饮食结合链脲佐菌素建立的T2DM小鼠模型。它发现 RPPs 治疗通过改善糖脂代谢和肝功能来缓解高血糖症状。免疫组化表明 RPPs 的降糖作用受 IRS-1/PI3K/AKT/GSK3β 信号通路调节。RPPs 治疗重塑肠道微生物群（odoribacter、Lachnospiraceae_NK4A136_group、乳酸杆菌、Turicibacter、丹毒梭菌和 Tuzzerella）的结构，并富集与 T2DM 小鼠糖尿病调节相关的代谢物（RPP 衍生的尿石素、短链脂肪酸、脱氢胆酸、（+）‐儿茶素、二氢小檗碱、紫檀芪和青蒿琥酯）。RPP 在改善糖脂代谢紊乱中的作用与差异的肠道微生物群和代谢物相关。结论肠道菌群及其代谢产物是 RPPs 降糖作用的关键靶点。