The prevalence of diabetic cognitive impairment (DCI) is significant, some studies have shown that it is related to mitochondrial respiratory chain homeostasis, but the specific mechanism is not clear. 2-hydroxyisobutyric acid (2-HIBA) is a novel short-chain fatty acid with potential applications in the treatment of metabolic diseases because it can regulate mitochondrial disorders. Our aim was to explore a novel mechanism of action for 2-HIBA in the treatment of DCI in mitochondrial respiratory chain homeostasis.

中文翻译：

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2-羟基异丁酸靶向结合 MT-ND3 促进海马线粒体呼吸链稳态以挽救糖尿病认知障碍


糖尿病认知障碍 （DCI） 的患病率显著，一些研究表明它与线粒体呼吸链稳态有关，但具体机制尚不清楚。2-羟基异丁酸 （2-HIBA） 是一种新型短链脂肪酸，可以调节线粒体疾病，因此在治疗代谢疾病方面具有潜在应用。我们的目的是探索 2-HIBA 治疗线粒体呼吸链稳态 DCI 的新作用机制。