Neurodegenerative diseases typically emerge after an extended prodromal period, underscoring the critical importance of initiating interventions during the early stages of brain aging to enhance later resilience. Changes in presynaptic active zone proteins ("PreScale") are considered a dynamic, resilience-enhancing form of plasticity in the process of early, still reversible aging of the Drosophila brain. Aging, however, triggers significant changes not only of synapses but also mitochondria. While the two organelles are spaced in close proximity, likely reflecting a direct functional coupling in regard to ATP and Ca2+ homeostasis, the exact modes of coupling in the aging process remain to understood.

中文翻译：

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线粒体状态与活性区可塑性在早期大脑衰老中的耦合


神经退行性疾病通常在较长的前驱期后出现，这凸显了在大脑衰老的早期阶段开始干预以增强后期恢复力的至关重要性。突触前活性区蛋白 （“PreScale”） 的变化被认为是果蝇大脑早期、仍然可逆衰老过程中的一种动态的、增强弹性的可塑性形式。然而，衰老不仅会引发突触的重大变化，还会引发线粒体的重大变化。虽然两个细胞器间隔得很近，可能反映了 ATP 和 Ca2+ 稳态的直接功能耦合，但衰老过程中的确切耦合模式仍有待了解。