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Serum peroxiredoxin-4, a biomarker of oxidative stress, associates with new-onset chronic kidney disease: A population-based cohort study
Redox Biology ( IF 10.7 ) Pub Date : 2024-10-22 , DOI: 10.1016/j.redox.2024.103408
Sem Geertsema, Paul Geertsema, Lyanne M. Kieneker, Amaal E. Abdulle, Sacha la Bastide-van Gemert, Stephan J.L. Bakker, Robin P.F. Dullaart, Gerard Dijkstra, Ron T. Gansevoort, Klaas Nico Faber, Harry van Goor, Arno R. Bourgonje

Chronic Kidney Disease (CKD), is often detected late due to its asymptomatic nature in the early stage of the disease. Overproduction of reactive oxygen species contributes to various pathological processes through oxidative stress (OS), impacting on cellular structures and functions with previous studies suggesting a link between OS and CKD progression. This study investigated the association between serum peroxiredoxin-4 (Prx4), a biomarker of oxidative stress, and the development of CKD in the general population.

中文翻译:


血清过氧化物还原蛋白-4 是氧化应激的生物标志物,与新发慢性肾病相关: 一项基于人群的队列研究



慢性肾病 (CKD) 由于在疾病早期无症状,因此通常被发现较晚。活性氧的过量产生通过氧化应激 (OS) 促进各种病理过程,影响细胞结构和功能,先前的研究表明 OS 与 CKD 进展之间存在联系。本研究调查了血清过氧化物还原蛋白-4 (Prx4)(氧化应激的生物标志物)与普通人群 CKD 发展之间的关联。
更新日期:2024-10-22
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