Challenges in the development of treatments for hereditary hearing loss include the exploration of the underlying pathological mechanisms, the comprehensive evaluation of safety and efficacy of gene therapies in clinical trials, the optimization of surgical approaches for drug delivery, and effective collaboration between industry and academia. Gene therapy for congenital deafness has made a breakthrough in recent clinical trials. However, more work is needed to develop successful treatments for hereditary hearing loss, as the authors argue in this Comment.

中文翻译：

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耳聋的基因治疗：我们可以做得更多


遗传性听力损失治疗方法开发的挑战包括探索潜在的病理机制、临床试验中基因疗法的安全性和有效性的综合评价、药物输送手术途径的优化以及产学界之间的有效合作。先天性耳聋的基因治疗在最近的临床试验中取得了突破。然而，正如作者在本评论中所论述的那样，需要更多的工作来开发成功的遗传性听力损失治疗方法。