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Aversion crosses over
Nature Neuroscience ( IF 21.2 ) Pub Date : 2024-12-03 , DOI: 10.1038/s41593-024-01842-w
Luis A. Mejia

Amygdalo–striatal neurons have been implicated in the processing of appetitive and aversive valence. Adding to our understanding of this neural pathway’s heterogeneity, Tian, Song et al. found that mice in which the anterior commissure was transected, which lack interhemispheric projections from basolateral amygdala (BLA) to contralateral nucleus accumbens (NAc), show blunted aversion. Strikingly, contralateral and ipsilateral BLA–NAc neurons were found to be largely separate populations. In intact mice, contralateral BLA–NAc neurons tended to be activated by aversive stimuli and suppressed by reward, whereas ipsilateral BLA–NAc neurons were activated by reward and suppressed by aversive stimuli. Selective activation and inhibition of contralateral neurons promoted and suppressed aversion, respectively, whereas ipsilateral neuron activation promoted appetitive behaviors. The authors showed that ipsilateral BLA–NAc neurons primarily target and activate D1 medium spiny neurons (MSNs) and might mediate appetitive valence by promoting dopamine release in the NAc. By contrast, contralateral BLA–NAc neurons primarily target D2 MSNs and mediate negative valence. These results extend our understanding of amygdalo-accumbal projection neurons and aversive coding in the brain.

Original reference: Science 386, eadp7520 (2024)



中文翻译:

 厌恶跨越


杏仁核-纹状体神经元与食欲和厌恶效价的处理有关。为了进一步理解这种神经通路的异质性,Tian, Song 等人发现,前连合被横切的小鼠缺乏从基底外侧杏仁核 (BLA) 到对侧伏隔核 (NAc) 的半球间投射,表现出迟钝的厌恶。引人注目的是,发现对侧和同侧 BLA-NAc 神经元在很大程度上是独立的群体。在完整小鼠中,对侧 BLA-NAc 神经元往往被厌恶刺激激活并被奖励抑制,而同侧 BLA-NAc 神经元被奖励激活并被厌恶刺激抑制。对侧神经元的选择性激活和抑制分别促进和抑制厌恶,而同侧神经元激活促进食欲行为。作者表明,同侧 BLA-NAc 神经元主要靶向和激活 D1 中等棘神经元 (MSN),并可能通过促进 NAc 中多巴胺的释放来介导食欲效价。相比之下,对侧 BLA-NAc 神经元主要靶向 D2 MSN 并介导负效价。这些结果扩展了我们对大脑中杏仁核-横隔投射神经元和厌恶编码的理解。


原始参考资料:Science386, eadp7520 (2024)

更新日期:2024-12-04
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