PAX5 controls the gene regulatory circuit that leads to B cell lineage commitment. A detailed study shows that the stability of PAX5 protein is reduced by acetylation, and that SIRT7-dependent deacetylation is required for full PAX5 activity.

中文翻译：

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B 系定型的翻译后控制


PAX5 控制导致 B 细胞谱系定型的基因调控回路。一项详细的研究表明，乙酰化会降低 PAX5 蛋白的稳定性，并且 PAX5 完全活性需要 SIRT7 依赖性脱乙酰化。