Tumor-infiltrating T cells are known to encounter chronic antigens and hypoxia, which results in exhaustion and dysfunction. New data show that lactate fermentation, a characteristic of solid tumors, promotes the uptake of lactate into T cells via the monocarboxylate transporter MCT11, which reduces the metabolic fitness and anti-tumor function of these cells, an effect that might be targeted by immunotherapy.

中文翻译：

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乳酸发酵使 TILs 中毒


已知肿瘤浸润 T 细胞会遇到慢性抗原和缺氧，从而导致疲惫和功能障碍。新数据显示，乳酸发酵是实体瘤的一个特征，通过单羧酸盐转运蛋白 MCT11 促进乳酸摄取到 T 细胞中，从而降低这些细胞的代谢适应性和抗肿瘤功能，免疫疗法可能针对这种作用。