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Metabolic–epigenetic rewiring in CD8+ T cells via lactate-dependent histone lactylation
Nature Immunology ( IF 27.7 ) Pub Date : 2024-10-16 , DOI: 10.1038/s41590-024-01991-x
Renqiang Sun, Hongbo Chi

The interplay of metabolites with epigenetic programs influences CD8+ T cell fate decisions. Here, Raychaudhuri et al. show that lactate-dependent histone lactylation tunes CD8+ T cell metabolism and function by regulating epigenetic and transcriptional remodeling.

中文翻译:


通过乳酸依赖性组蛋白乳基化在 CD8+ T 细胞中进行代谢-表观遗传再连接



代谢物与表观遗传程序的相互作用会影响 CD8+ T 细胞命运的决定。在这里,Raychaudhuri 等人表明,乳酸依赖性组蛋白乳酸化通过调节表观遗传和转录重塑来调节 CD8+ T 细胞代谢和功能。
更新日期:2024-10-16
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