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Targeting systemic IL-2 to BCMA CAR-T cells
Nature Immunology ( IF 27.7 ) Pub Date : 2024-10-15 , DOI: 10.1038/s41590-024-01993-9
Yuzhe Shi, Michel Sadelain

CAR-T cells are revolutionizing the treatment of cancer and other diseases. A latest iteration in development involves fusion with an antigen-based CAR enhancer to provide low-affinity IL-2 signaling that might limit adverse effects.

中文翻译:


将全身性 IL-2 靶向 BCMA CAR-T 细胞



CAR-T 细胞正在彻底改变癌症和其他疾病的治疗。最新开发的迭代涉及与基于抗原的 CAR 增强子融合,以提供可能限制不良反应的低亲和力 IL-2 信号传导。
更新日期:2024-10-15
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