The cellular environment is critical to protein function. How is information from many cellular components decoded in order to fine-tune biological activity? New models of biomolecular recognition raise the possibility that proteins engage in specific, yet fuzzy, interactions with their functional partners, which can provide a readout mechanism of the cellular context. Manipulating the cellular context to control protein function offers new therapeutic opportunities. In this Comment article, Monika Fuxreiter discusses possible roles of dynamic, fuzzy protein interactions and their importance in changing cellular environments.

中文翻译：

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蛋白质如何感知其细胞环境


细胞环境对蛋白质功能至关重要。如何解码来自许多细胞成分的信息以微调生物活性？新的生物分子识别模型提高了蛋白质与其功能伙伴进行特异性但模糊的相互作用的可能性，这可以提供细胞环境的读出机制。操纵细胞环境以控制蛋白质功能提供了新的治疗机会。在这篇评论文章中，Monika Fuxreiter 讨论了动态、模糊蛋白质相互作用的可能作用及其在不断变化的细胞环境中的重要性。