The development of sustainable trifluoromethylations of enamides is of great interest to the pharmaceutical industry. Herein, we demonstrate a sustainable direct electrochemical trifluoromethylation method in a microflow cell, using Langlois reagent, without the need for a supporting electrolyte, oxidants, or any additive under mild conditions. This method can be applied to various substrates with a yield of up to 84%. Additionally, the batch process yielded significantly less (22%), highlighting the microflow cell’s efficiency.

中文翻译：

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微流条件下烯酰胺的电化学三氟甲基化


烯酰胺可持续三氟甲基化的开发对制药行业非常感兴趣。在本文中，我们展示了一种在微流池中使用 Langlois 试剂的可持续直接电化学三氟甲基化方法，在温和条件下不需要支持电解质、氧化剂或任何添加剂。该方法可应用于各种基材，产量高达 84%。此外，批处理过程的产量明显降低 （22%），突出了微流池的效率。