A variety of structurally diverse spirocyclohexane oxindoles featuring a quaternary carbon centre have been successfully constructed through an N‐heterocyclic carbene‐catalyzed [4+2] annulation of isatin‐derived enals with α cyano‐β‐methylenones. This domino process exhibits a wide substrate tolerance, operates under mild conditions, and yields products with high enantioselectivity.

中文翻译：

---

N-杂环卡宾催化的螺环己烷氧吲哚的对映选择性合成


通过菲丁衍生的烯醛与 α 个氰基-β-甲基烯酮的 N-杂环卡宾催化 [4+2] 环状元，已成功构建了多种结构多样的具有季碳中心的螺环己烷氧吲哚。这种 Domino 工艺表现出广泛的底物耐受性，在温和的条件下运行，并产生具有高对映选择性的产品。