This work provides an in‐depth analysis of the factors governing the different reaction pathways in the acid‐catalyzed cyclization of gem‐vinylsilyl alcohols with aldehydes. The study evaluates the impact of both the ligands attached to silicon and the choice of the Lewis acid on the reaction outcome. Additionally, computational studies offer valuable insights into the mechanism that control these distinct pathways. The process enables the chemo‐ and stereocontrolled formation of a variety of structural frameworks, offering significant potential for the generation of a broad range of molecular architectures.

中文翻译：

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深入了解影响 gem-乙烯基甲硅烷醇的 Silyl-Prins 环化反应途径的关键因素


这项工作深入分析了在酸催化的 gem-乙烯基甲硅烷醇与醛的环化过程中控制不同反应途径的因素。该研究评估了连接到硅上的配体和路易斯酸的选择对反应结果的影响。此外，计算研究为控制这些不同途径的机制提供了有价值的见解。该过程能够形成各种结构框架的化学和立体控制，为产生广泛的分子结构提供了巨大的潜力。