The direct synthesis of organic phosphorus compounds from white phosphorus (P₄) is a longstanding challenge in organic synthesis. Here, we present a novel visible light-induced three-component functionalization reaction that integrates P₄, disulfide compounds, and N-hydroxyphthalimide (NHPI) esters to produce alkyl-substituted phosphonodithioates in a one-pot process. Using 2,4,5,6-tetrakis(carbazol-9-yl)-1,3-dicyanobenzene (4CzIPN) as a photocatalyst, blue LEDs (456 nm) as the light source, and N,N-diisopropylethylamine (DIPEA) as the reducing agent in an acetone-toluene solvent system, this method achieves moderate to good yields of structurally diverse phosphonodithioates. The reaction proceeds under mild conditions, ensures complete conversion of P₄, avoids chlorination, and uses inexpensive, readily available starting materials, offering potential for large-scale applications.

从白磷 （P₄） 直接合成有机磷化合物是有机合成中一个长期的挑战。在这里，我们提出了一种新型的可见光诱导的三组分官能团化反应，该反应将 P₄、二硫化物化合物和 N-羟基邻苯二酰亚胺 （NHPI） 酯整合在一起，在一锅法工艺中生产烷基取代的膦酰硫代酸酯。使用2,4,5,6-四（咔唑-9-基）-1,3-二氰基苯（4CzIPN）作为光催化剂，蓝色LED（456 nm）作为光源，N，N-二异丙基乙胺（DIPEA）作为丙酮-甲苯溶剂系统中的还原剂，该方法实现了结构多样的膦酰硫酸盐的中等到良好产率。该反应在温和的条件下进行，确保 P₄ 的完全转化，避免氯化，并使用廉价、现成的起始材料，为大规模应用提供了潜力。