The combination of palladium and silver complexes has emerged as a bimetallic catalytic system in C−H activation, frequently outperforming palladium‐only systems. Beyond the conventional roles of silver (I) salts serving as oxidants, halide scavengers, and Lewis acids, Pd−Ag bimetallic synergism has been shown to facilitate C−H cleavage. In this study, we explore the incorporation of a pyrazolopyridone (PzPyOH) ligand into a Pd−Ag bimetallic catalytic system, which together promote both C−H cleavage and migratory insertion processes. This synergistic approach enables dehydrogenative C−H alkenylations at the C4 position of 2,1,3‐benzothiadiazole, 2,1,3‐benzoxadiazole, and 2,1,3‐benzotriazole with alkenes. These results demonstrate the potential of combining novel ligands with heterobimetallic systems to facilitate other elementary steps beyond C−H cleavage, suggesting their broader applicability in C−H functionalization.

中文翻译：

---

协同钯/银/配体催化 2,1,3-苯并异重唑的 C-H 烯基化反应


钯和银配合物的组合已成为 C-H 活化中的双金属催化系统，其性能通常优于纯钯系统。除了银 （I） 盐作为氧化剂、卤化物清除剂和路易斯酸的常规作用外，Pd-Ag 双金属增效作用已被证明可促进 C-H 裂解。在这项研究中，我们探索了吡唑并吡啶酮 （PzPyOH） 配体掺入 Pd-Ag 双金属催化体系，它们共同促进 C-H 切割和迁移插入过程。这种协同方法能够在 2,1,3-苯并噻二唑、2,1,3-苯并噁二唑和 2,1,3-苯并三唑与烯烃的 C4 位置进行脱氢 C-H 烯基化。这些结果表明，将新型配体与异双金属系统相结合的潜力，可以促进 C-H 切割以外的其他基本步骤，表明它们在 C-H 官能团化中具有更广泛的适用性。