The chromium‐catalysed Nozaki‐Hiyama‐Kishi (NHK) reaction is a very dependable technique for alcohol synthesis and is extensively used in the complete synthesis of natural compounds. The majority of these reactions occur via a reductive‐radical‐polar crossover (RRPCO) mechanism, which is crucial for the transformation of reactive radical intermediates. The production of radicals using photoinduced catalytic reactions is now among the most effective approaches. The photoinduced chromium‐catalysed addition reaction to carbonyl compounds is an effective technique for alcohol synthesis that integrates the benefits of photocatalysis with chromium catalysis. Photocatalysis significantly enhances the diversity of radical production, hence broadening the substrate scope in the chromium‐catalysed NHK reaction. This paper primarily examines the photoredox chromium dual‐catalysed carbonyl addition process for alcohol synthesis, including numerous methods for radical generation.

中文翻译：

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光氧化还原/铬双催化羰基加成反应研究进展综述


铬催化的野崎-桧山-贵 （NHK） 反应是一种非常可靠的醇合成技术，广泛用于天然化合物的完全合成。这些反应中的大多数通过还原-自由基-极叉 （RRPCO） 机制发生，这对于反应性自由基中间体的转化至关重要。使用光诱导催化反应生产自由基是目前最有效的方法之一。光诱导铬催化羰基化合物加成反应是一种有效的醇合成技术，它结合了光催化与铬催化的优点。光催化显着增强了自由基产生的多样性，从而拓宽了铬催化 NHK 反应中的底物范围。本文主要研究了用于醇合成的光氧化还原铬双催化羰基加成工艺，包括许多自由基生成方法。