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Base-Mediated Sequential Annulation Reaction of Conjugated Dienes and Crotonate-Derived Sulfur Ylides:Effective Synthesis of Bicyclo[4.1.0]heptenes
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2024-11-25 , DOI: 10.1002/adsc.202401273 Zhenjie Gan, Jingran Sun, Zhangyun Huang, Zhenjue Cai, Yue Wang, Er-Qing Li
中文翻译:
碱介导的共轭二烯和巴豆酸盐衍生的硫酰化物的连续环化反应:双环[4.1.0]庚烯的有效合成
更新日期:2024-11-25
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2024-11-25 , DOI: 10.1002/adsc.202401273 Zhenjie Gan, Jingran Sun, Zhangyun Huang, Zhenjue Cai, Yue Wang, Er-Qing Li
Herein we present a method for base-mediated sequential annulation reaction of conjugated dienes. The method offers an efficient pathway for the effective construction of bicyclo[4.1.0]heptenes. Notable features of this approach include good yields, remarkable stereoselectivity, as well as a broad substrate scope and significant step efficiency. In addition, the reaction could be effectively scaled up to a gram scale under standard condition.
中文翻译:
碱介导的共轭二烯和巴豆酸盐衍生的硫酰化物的连续环化反应:双环[4.1.0]庚烯的有效合成
在此,我们提出了一种碱基介导的共轭二烯顺序环化反应的方法。该方法为有效构建双环[4.1.0]庚烯提供了一种有效的途径。这种方法的显着特点包括良好的产量、显着的立体选择性,以及广泛的底物范围和显着的步长效率。此外,在标准条件下,反应可以有效地放大至克级。