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Synthesis and Antibacterial Evaluation of Prenylacridone Alkaloids and Analogues
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2024-12-20 , DOI: 10.1039/d4qo02126f Shilpi Karmakara, Kousik Maji, Sudeshna Mondal, Semantee Bhattacharya, Jyotirmayee Dash
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2024-12-20 , DOI: 10.1039/d4qo02126f Shilpi Karmakara, Kousik Maji, Sudeshna Mondal, Semantee Bhattacharya, Jyotirmayee Dash
A concise total synthesis of natural prenylacridone alkaloids, N-methylcycloatalaphylline A, N-methylbuxifoliadine D, buxifoliadine D, oriciacridone E, glycocitrine II, norglycocitrine II, 3-O-methoxyglycocitrine II and new series of their non-natural analogues with diverse functionalities is achieved. Antibacterial assays of these alkaloids revealed that difluoro glycocitrine II derivative exhibits highest potency against Streptococcus species.
更新日期：2024-12-20
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