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Steric Hindrance Tuned [4 + 1] Annulation of α-Substituted Conjugated Enones with Ylides for Dihydrofuran Synthesis
Organic Letters ( IF 4.9 ) Pub Date : 2024-12-19 , DOI: 10.1021/acs.orglett.4c03930 Jiaxin Chu, Haoran Wang, Sunewang R. Wang
Organic Letters ( IF 4.9 ) Pub Date : 2024-12-19 , DOI: 10.1021/acs.orglett.4c03930 Jiaxin Chu, Haoran Wang, Sunewang R. Wang
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In sharp contrast to the intuitive modulation by the electronic effect, the [4 + 1] annulation reaction between α-substituted conjugated enones and ylides has been reliably controlled by the match of the α-substituent and the ylide in steric hindrance, providing a straightforward and efficient method for valuable 4-cyano, 4-alkynyl, 4-vinyl, and 4-aryl 2,3-dihydrofurans.
更新日期：2024-12-20
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