An effective and economical copper-catalyzed approach for the synthesis of phosphorylated 1H-isochromenes is reported. This method is the first example of focus on ketone phosphonylation to establish a C–P bond and 6-endo-dig cyclization to construct a C–O bond between aryl- and alkyl-substituted alkynylketones and H-phosphinate esters, H-phosphites, and H-phosphine oxides, resulting in chemo- and regioselective phosphorylated 1H-isochromenes with moderate to excellent yields under smooth reaction conditions.

中文翻译：

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铜催化的 Domino 磷酸化/邻位炔烃的环化反应，用于获得磷酸化的 1H-异色素


报道了一种有效且经济的铜催化合成磷酸化 1H-异色子的方法。该方法是第一个专注于酮膦酰化以建立 C-P 键和 6-endo-dig 环化以在芳基和烷基取代的炔基酮与 H-次膦酸酯、H-亚磷酸酯和 H-膦氧化物之间构建 C-O 键的第一个例子，从而在平滑反应条件下产生化学和区域选择性磷酸化 1H-异色醇，产率中等至极高。