A bioinspired alkylation dearomatization reaction was developed to construct the 5/6/6 fused-spiro tricyclic core framework and spiro-quaternary carbon chiral center. The usage of this approach for assembling these natural products of spirocyclic polycyclic polyprenylated acylphloroglucinols with an octahydrospiro-[cyclohexan-1,5′-indene] core is demonstrated by the first asymmetric total synthesis of highly oxidized hyperbeanol A.

中文翻译：

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（+）-Hyperbeanol A 的不对称全合成


开发了一种生物启发烷基化脱芳烃反应，以构建 5/6/6 熔融螺三环核心框架和螺-季碳手性中心。使用这种方法将螺环多环聚戊二烯酰化酰基间苯三酚与八氢螺-[环己烷-1,5′-茚] 核心的这些天然产物组装起来，由高度氧化的高豆醇 A 的首次不对称全合成证明。