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Carboxylations of (Hetero)Aromatic C–H Bonds Using an Alkyl Silyl Carbonate Reagent
Organic Letters ( IF 4.9 ) Pub Date : 2024-12-20 , DOI: 10.1021/acs.orglett.4c04388 Kanta Shimotai, Ozora Sasamoto, Masanori Shigeno
Organic Letters ( IF 4.9 ) Pub Date : 2024-12-20 , DOI: 10.1021/acs.orglett.4c04388 Kanta Shimotai, Ozora Sasamoto, Masanori Shigeno
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In this paper, we report that the use of an alkyl silyl carbonate reagent combined with CsF and 18-crown-6 facilitates efficient direct carboxylations of (hetero)aromatic C–H bonds. This system also enables benzylic carboxylation of a toluene derivative and double carboxylation of methyl heteroarene. The carbonate reagent is characterized by its ease of handling and storage. Moreover, we demonstrate the application of this system in 13C-labeling experiments.
更新日期：2024-12-20
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