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Palladium-Catalyzed Decarboxylative Domino Synthesis of Fused Quinolin-2(1H)-one Scaffolds Containing Perfluoroalkyl Unit
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2024-12-20 , DOI: 10.1039/d4qo01970a Shuwei Li, Linqi Wang, Shangyuan Wang, Jun Ying
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2024-12-20 , DOI: 10.1039/d4qo01970a Shuwei Li, Linqi Wang, Shangyuan Wang, Jun Ying
A novel palladium-catalyzed domino radical cyclization and C-H activation/decarboxylation of 1,7-enynes with o-bromobenzoic acids and perfluoroalkyl iodides has been developed for the expedite construction of fused perfluoroalkyl-containing quinolin-2(1H)-one scaffolds. This method provides a facile synthesis of fused quinolin-2(1H)-one derivatives containing perfluoroalkyl unit in high yields. Notably, the late-stage modifications of various drugs were also demonstrated by using this method.
更新日期：2024-12-20
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