A novel and highly efficient Pd-catalyzed approach for the synthesis of bis-heterocycles featuring both isoxazoline and methyleneindole motifs is demonstrated. The in situ formation of vinyl Pd(II) species through an alkyne-tethered carbamoyl chloride cyclization is crucial, and the innovative Pd-catalyzed carboetherification of β,γ-unsaturated oximes with vinyl Pd(II) species has been developed. This method is not only operationally straightforward but also exhibits a broad substrate scope and excellent functional group tolerance.

中文翻译：

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钯催化的 Domino 碳醚化反应：合成带有异恶唑啉和亚甲基吲哚基序的双杂环


展示了一种新颖且高效的 Pd 催化合成具有异恶唑啉和亚甲基吲哚基序的双杂环的方法。通过炔烃束缚氨基甲酰氯环化原位形成乙烯基 Pd（II） 物种至关重要，并且已经开发了 β，γ-不饱和肟与乙烯基 Pd（II） 物种的创新 Pd 催化碳醚化。这种方法不仅操作简单，而且具有广泛的底物范围和出色的官能团耐受性。