Actinomycete bacteria derived from marine environments are a good source of natural products with diverse biological activities such as cytotoxicity, antiviral, and antimicrobial actions. This review summarizes 191 angucyclines and angucyclinones derived from marine actinomycetes reported in the literature from 2014 to 2023 and introduced the latest developments in actinomycete-silenced biosynthetic gene cluster activation, including heterologous recombination and in situ activation. The key role of redox post-modifications in the biosynthetic process of atypical angucyclines. This review provides insights into the discovery and biosynthesis of valuable angucyclines and angucyclinones from marine-associated actinomycetes and potential lead compounds for the research and development of new drugs.

中文翻译：

---

海洋放线菌衍生的具有生物合成和活性的 Angucyclines 和 Angucyclinones - 过去 10 年 （2014–2023）


源自海洋环境的放线菌是天然产物的良好来源，具有多种生物活性，如细胞毒性、抗病毒和抗菌作用。本文总结了 2014—2023 年文献报道的 191 种来源于海洋放线菌的 Angucyclines 和 Angucyclinones，并介绍了放线菌沉默生物合成基因簇激活的最新进展，包括异源重组和原位激活。氧化还原后修饰在非典型 Angucyclines 生物合成过程中的关键作用。本文综述为从海洋相关放线菌中发现和生物合成有价值的 Angucyclines 和 Angucyclinones 以及用于新药研发的潜在先导化合物提供了见解。