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Lifespan differences in hippocampal subregion connectivity patterns during movie watching Neurobiol. Aging (IF 3.7) Pub Date : 2024-06-30 Can Fenerci, Roni Setton, Giulia Baracchini, Jamie Snytte, R. Nathan Spreng, Cam CAN, Signy Sheldon
Age-related episodic memory decline is attributed to functional alternations in the hippocampus. Less clear is how aging affects the functional connections of the hippocampus to the rest of the brain during episodic memory processing. We examined fMRI data from the CamCAN dataset, in which a large cohort of participants watched a movie (N = 643; 18–88 years), a proxy for naturalistic episodic memory
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Reduced PIN1 expression in neocortical and limbic brain regions in female Alzheimer’s patients correlates with cognitive and neuropathological phenotypes Neurobiol. Aging (IF 3.7) Pub Date : 2024-06-29 Camila de Ávila, Crystal Suazo, Jennifer Nolz, J. Nicholas Cochran, Qi Wang, Ramon Velazquez, Eric Dammer, Benjamin Readhead, Diego Mastroeni
Women have a higher incidence of Alzheimer’s disease (AD), even after adjusting for increased longevity. Thus, there is an urgent need to identify genes that underpin sex-associated risk of AD. PIN1 is a key regulator of the tau phosphorylation signaling pathway; however, potential differences in PIN1 expression, in males and females, are still unknown. We analyzed brain transcriptomic datasets focusing
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Age-related differences in retinal function and structure in C57BL/6J and Thy1-YFPh mice Neurobiol. Aging (IF 3.7) Pub Date : 2024-06-26 Pei Ying Lee, Bang V. Bui
Age-related neuronal adaptations are known to help maintain function. This study aims to examine gross age-related retinal functional adaptations (using electroretinography) in young and middle aged C57BL/6J and Thy1-YFPh mice and to relate this to retinal structure (using optical coherence tomography). Electroretinography responses were generally larger in Thy1-YFPh mice than in C57BL/6J mice, with
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Associations of cerebrovascular disease and Alzheimer’s disease pathology with cognitive decline: Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set Neurobiol. Aging (IF 3.7) Pub Date : 2024-06-21 Ankita Chatterjee, Shannon Lee, Valentina Diaz, Rowan Saloner, Mark Sanderson-Cimino, Charles deCarli, Pauline Maillard, Jason Hinman, Keith Vossel, Kaitlin B. Casaletto, Adam M. Staffaroni, Emily W. Paolillo, Joel H. Kramer
Cerebrovascular disease (CVD) and Alzheimer’s disease (AD) often co-occur and may impact specific cognitive domains. This study’s goal was to determine effects of CVD and AD burden on cross-sectional and longitudinal executive function (EF) and memory in older adults.
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Cerebrospinal fluid biomarkers and cognitive trajectories in patients with Alzheimer’s disease and a history of traumatic brain injury Neurobiol. Aging (IF 3.7) Pub Date : 2024-06-14 Suzan van Amerongen, Shreyasee Das, Suzie Kamps, Julie Goossens, Bram Bongers, Yolande A.L. Pijnenburg, Eugeen Vanmechelen, Everard G.B. Vijverberg, Charlotte E. Teunissen, Inge M.W. Verberk
Traumatic brain injury (TBI) and Alzheimer’s disease (AD) have overlapping mechanisms but it remains unknown if pathophysiological characteristics and cognitive trajectories in AD patients are influenced by TBI history. Here, we studied AD patients (stage MCI or dementia) with TBI history (AD n=110), or without (AD, n=110) and compared baseline CSF concentrations of amyloid beta 1–42 (Aβ42), phosphorylated
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Menopause status- and sex-related differences in age associations with spatial context memory and white matter microstructure at midlife Neurobiol. Aging (IF 3.7) Pub Date : 2024-06-08 Rikki Lissaman, Sricharana Rajagopal, Julia Kearley, Stamatoula Pasvanis, Maria Natasha Rajah
Decline in spatial context memory emerges in midlife, the time when most females transition from pre- to post-menopause. Recent evidence suggests that, among post-menopausal females, advanced age is associated with functional brain alterations and lower spatial context memory. However, it is unknown whether similar effects are evident for white matter (WM) and, moreover, whether such effects contribute
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Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans Neurobiol. Aging (IF 3.7) Pub Date : 2024-06-03 Sandra Aleksic, Roman Fleysher, Erica F. Weiss, Noa Tal, Timothy Darby, Helena M. Blumen, Juan Vazquez, Kenny Q. Ye, Tina Gao, Shira M. Siegel, Nir Barzilai, Michael L. Lipton, Sofiya Milman
The hypothalamus regulates homeostasis across the lifespan and is emerging as a regulator of aging. In murine models, aging-related changes in the hypothalamus, including microinflammation and gliosis, promote accelerated neurocognitive decline. We investigated relationships between hypothalamic microstructure and features of neurocognitive aging, including cortical thickness and cognition, in a cohort
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Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease Neurobiol. Aging (IF 3.7) Pub Date : 2024-06-01 Blanca Rodríguez-Fernández, Gonzalo Sánchez-Benavides, Patricia Genius, Carolina Minguillon, Karine Fauria, Immaculata De Vivo, Arcadi Navarro, Jose Luis Molinuevo, Juan Domingo Gispert, Aleix Sala-Vila, Natalia Vilor-Tejedor, Marta Crous-Bou, for the ALFA study
Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. A total of 1520 participants from the ALFA cohort were included. Relative telomere
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The relationship between cortical thickness and white matter hyperintensities in mid to late life Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-29 Joan Jiménez-Balado, Christian Habeck, Yaakov Stern, Teal Eich
White matter hyperintensities (WMH) are associated with cortical thinning. Although they are primarily detected in older participants, these lesions can appear in younger and midlife individuals. Here, we tested whether WMH are associated with cortical thinning in relatively younger (26–50 years) and relatively older (58–84) participants who were free of dementia, and how these associations are moderated
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Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer’s disease Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-29 Stephanie Lindgård Knudtzon, Kaja Nordengen, Gøril Rolfseng Grøntvedt, Jonas Jarholm, Ingvild Vøllo Eliassen, Per Selnes, Lene Pålhaugen, Jacob Espenes, Berglind Gísladóttir, Knut Waterloo, Tormod Fladby, Bjørn-Eivind Kirsebom
Cerebrospinal fluid total-tau (t-tau) and neurofilament light chain (NfL) are biomarkers of neurodegeneration and are increased in Alzheimer’s disease (AD). In order to adjust for age-related increases in t-tau and NfL, cross-sectional age-adjusted norms were developed based on amyloid negative cognitively normal (CN) adults aged 41–78 years (CN, n = 137). The age-adjusted norms for t-tau and NfL did
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Hippocampal subfield volume in older adults with and without mild cognitive impairment: Effects of worry and cognitive reappraisal Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-28 Helmet T. Karim, Soyoung Lee, Andrew Gerlach, Mark Stinley, Rachel Berta, Rebecca Mahbubani, Dana L. Tudorascu, Meryl A. Butters, James J. Gross, Carmen Andreescu
Studies have confirmed that anxiety, especially worry and rumination, are associated with increased risk for cognitive decline, including Alzheimer’s disease and related dementias (ADRD). Hippocampal atrophy is a hallmark of ADRD. We investigated the association between hippocampus and its subfield volumes and late-life global anxiety, worry, and rumination, and emotion regulation strategies. We recruited
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Cognitive reserve proxies are associated with age-related cognitive decline – Not age-related gait speed decline Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-27 Helena M. Blumen, Oshadi Jayakody, Emmeline Ayers, Nir Barzilai, Christian Habeck, Sofiya Milman, Yaakov Stern, Erica F. Weiss, Joe Verghese
Cognition and gait share brain substrates in aging and dementia. Cognitive reserve (CR) allows individuals to cope with brain pathology and delay cognitive impairment and dementia. Yet, evidence for that CR is associated with age-related cognitive decline is mixed, and evidence for that CR is associated with age-related gait decline is limited. In 1,079 older ( Age = 75.4 years; 56.0% women) LonGenity
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Modulation of dorsal premotor cortex differentially influences visuomotor adaptation in young and older adults Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-25 Wei-Yeh Liao, George M. Opie, Ulf Ziemann, John G. Semmler
The communication between dorsal premotor cortex (PMd) and primary motor cortex (M1) is important for visuomotor adaptation, but it is unclear how this relationship changes with advancing age. The present study recruited 21 young and 23 older participants for two experimental sessions during which intermittent theta burst stimulation (iTBS) or sham was applied over PMd. We assessed the effects of PMd
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Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-23 Andrea Mendez Colmenares, Michael L. Thomas, Charles Anderson, David B. Arciniegas, Vince Calhoun, In-Young Choi, Arthur F. Kramer, Kaigang Li, Jongho Lee, Phil Lee, Agnieszka Z. Burzynska
The "structural disconnection" hypothesis of cognitive aging suggests that deterioration of white matter (WM), especially myelin, results in cognitive decline, yet in vivo evidence is inconclusive. We examined age differences in WM microstructure using Myelin Water Imaging and Diffusion Tensor Imaging in 141 healthy participants (age 20–79). We used the Virginia Cognitive Aging Project and the NIH
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Interstitial fluid flow decreases with age, especially after 50 years Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-19 Yuji Suzuki, Yukimi Nakamura, Hironaka Igarashi
Physiological age-related alterations in the interstitial flow in the brain, which plays an important role in waste product removal, remain unclear. Using [O]HO positron emission tomography (PET), water dynamics were evaluated in 63 healthy adult participants aged between 20 and 80 years. Interstitial flow was assessed by influx ratio (IR) and drain rate (DR), using time-activity concentration data
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Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-18 Michele Cavallari, Alexandra Touroutoglou, Yuta Katsumi, Tamara G. Fong, Eva Schmitt, Thomas G. Travison, Mouhsin M. Shafi, Towia A. Libermann, Edward R. Marcantonio, David C. Alsop, Richard N. Jones, Sharon K. Inouye, Bradford C. Dickerson, for the SAGES study group
In older patients, delirium after surgery is associated with long-term cognitive decline (LTCD). The neural substrates of this association are unclear. Neurodegenerative changes associated with dementia are possible contributors. We investigated the relationship between brain atrophy rates in Alzheimer’s disease (AD) and cognitive aging signature regions from magnetic resonance imaging before and one
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Brain reserve in midlife is associated with executive function changes across 12 years Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-16 Daniel E. Gustavson, Jeremy A. Elman, Chandra A. Reynolds, Lisa T. Eyler, Christine Fennema-Notestine, Olivia K. Puckett, Matthew S. Panizzon, Nathan A. Gillespie, Michael C. Neale, Michael J. Lyons, Carol E. Franz, William S. Kremen
We examined how brain reserve in midlife, measured by brain-predicted age difference scores (Brain-PADs), predicted executive function concurrently and longitudinally into early old age, and whether these associations were moderated by young adult cognitive reserve or genotype. 508 men in the Vietnam Era Twin Study of Aging (VETSA) completed neuroimaging assessments at mean age 56 and six executive
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Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-16 Ana T. Vitantonio, Christina Dimovasili, Farzad Mortazavi, Kelli L. Vaughan, Julie A. Mattison, Douglas L. Rosene
Calorie restriction (CR) is a robust intervention that can slow biological aging and extend lifespan. In the brain, terminally differentiated neurons and glia accumulate oxidative damage with age, reducing their optimal function. We investigated if CR could reduce oxidative DNA damage to white matter oligodendrocytes and microglia. This study utilized post-mortem brain tissue from rhesus monkeys that
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Isoform-specific effects of neuronal inhibition of AMPK catalytic subunit on LTD impairments in a mouse model of Alzheimer’s disease Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-15 Qian Yang, Xueyan Zhou, Tao Ma
Synaptic dysfunction is highly correlated with cognitive impairments in Alzheimer’s disease (AD), the most common dementia syndrome in the elderly. Long-term potentiation (LTP) and long-term depression (LTD) are two primary forms of synaptic plasticity with opposite direction of synaptic efficiency change. Both LTD and LTD are considered to mediate the cellular process of learning and memory. Substantial
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Multiscale brain age prediction reveals region-specific accelerated brain aging in Parkinson's disease Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-14 Yueh-Sheng Chen, Chen-Yuan Kuo, Cheng-Hsien Lu, Yuan-Wei Wang, Kun-Hsien Chou, Wei-Che Lin
Brain biological age, which measures the aging process in the brain using neuroimaging data, has been used to assess advanced brain aging in neurodegenerative diseases, including Parkinson disease (PD). However, assuming that whole brain degeneration is uniform may not be sufficient for assessing the complex neurodegenerative processes in PD. In this study we constructed a multiscale brain age prediction
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Corticomuscular and intermuscular coherence as a function of age and walking balance difficulty Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-13 Andréia Abud da Silva Costa, Renato Moraes, Rob den Otter, Federico Gennaro, Lisanne Bakker, Paulo Cezar Rocha dos Santos, Tibor Hortobágyi
We determined beta-band intermuscular (IMC) and corticomuscular coherence (CMC) as a function of age and walking balance difficulty. Younger (n=14, 23y) and older individuals (n=19, 71y) walked 13 m overground, on a 6-cm-wide ribbon overground, and on a 6-cm-wide (5-cm-high) beam. Walking distance as a proxy for walking balance and speed were computed. CMC was estimated between electroencephalographic
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Astrocytic-derived vascular remodeling factors are independently associated with blood brain barrier permeability in Alzheimer’s disease Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-13 Francesca Bernocchi, Chiara Giuseppina Bonomi, Martina Assogna, Alessandra Moreschini, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Motta
Astrocytes in Alzheimer’s disease (AD) exert a pivotal role in the maintenance of blood-brain barrier (BBB) integrity essentially through structural support and release of soluble factors. This study provides new insights into the vascular remodeling processes occurring in AD, and reveals, , a pathological profile of astrocytic secretion involving Vascular Endothelial Growth Factor (VEGF), Matrix Metalloproteinases
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Region-specific and age-related differences in astrocytes in the human brain Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-13 Jodie H.K. Man, Marjolein Breur, Charlotte A.G.H. van Gelder, Gabriella Marcon, Emanuela Maderna, Giorgio Giaccone, Maarten Altelaar, Marjo S. van der Knaap, Marianna Bugiani
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Degree of multilingual engagement modulates resting state oscillatory activity across the lifespan Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-04 Toms Voits, Vincent DeLuca, Jiuzhou Hao, Kirill Elin, Jubin Abutalebi, Jon Andoni Duñabeitia, Gaute Berglund, Anders Gabrielsen, Janine Rook, Hilde Thomsen, Philipp Waagen, Jason Rothman
Multilingualism has been demonstrated to lead to a more favorable trajectory of neurocognitive aging, yet our understanding of its effect on neurocognition across the lifespan remains limited. We collected resting state EEG recordings from a sample of multilingual individuals across a wide age range. Additionally, we obtained data on participant multilingual language use patterns alongside other known
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Age- and sex- divergent translatomic responses of the mouse retinal pigmented epithelium Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-03 Ana J. Chucair-Elliott, Sarah R. Ocañas, Kevin Pham, Adeline Machalinski, Scott Plafker, Michael B. Stout, Michael H. Elliott, Willard M. Freeman
Aging is the main risk factor for age-related macular degeneration (AMD), a retinal neurodegenerative disease that leads to irreversible blindness, particularly in people over 60 years old. Retinal pigmented epithelium (RPE) atrophy is an AMD hallmark. Genome-wide chromatin accessibility, DNA methylation, and gene expression studies of AMD and control RPE demonstrate epigenomic/transcriptomic changes
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Reserve, resilience and maintenance of episodic memory and other cognitive functions in aging Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-01 Claudia Schwarz, Carol E. Franz, William S. Kremen, Eero Vuoksimaa
We tested if cognitive and brain reserve and maintenance explain individual differences in episodic memory and other cognitive domains from late middle to early older adulthood. We used The Vietnam Era Twin Study of Aging data (n=1604 men) with episodic memory measured at mean ages of 56, 62 and 68 years, and magnetic resonance imaging data for a subsample of participants (n=321). Cognitive reserve
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High-fat diet and aging-associated memory impairments persist in the absence of microglia in female rats Neurobiol. Aging (IF 3.7) Pub Date : 2024-05-01 Sajida Malik, Soniya Xavier, Alita Soch, Simin Younesi, Jackson Yip, Mary Slayo, Ruth M. Barrientos, Luba Sominsky, Sarah J. Spencer
Aging is associated with a priming of microglia such that they are hypersensitive to further immune challenges. As such high-fat diet during aging can have detrimental effects on cognition that is not seen in the young. However, conflicting findings also suggest that obesity may protect against cognitive decline during aging. Given this uncertainty we aimed here to examine the role of microglia in
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Age-related differences in functional connectivity associated with pain modulation Neurobiol. Aging (IF 3.7) Pub Date : 2024-04-25 Marian van der Meulen, Katharina M. Rischer, Ana María González Roldán, Juan Lorenzo Terrasa, Pedro Montoya, Fernand Anton
Growing evidence suggests that aging is associated with impaired endogenous pain modulation, and that this likely underlies the increased transition from acute to chronic pain in older individuals. Resting-state functional connectivity (rsFC) offers a valuable tool to examine the neural mechanisms behind these age-related changes in pain modulation. RsFC studies generally observe decreased within-network
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Slow wave activity disruptions and memory impairments in a mouse model of aging Neurobiol. Aging (IF 3.7) Pub Date : 2024-04-25 Lu Yu, Alyssa N. Russ, Moustafa Algamal, Md Joynal Abedin, Qiuchen Zhao, Morgan R. Miller, Stephen J. Perle, Ksenia V. Kastanenka
The aging population suffers from memory impairments. Slow-wave activity (SWA) is composed of slow (0.5–1 Hz) and delta (1–4 Hz) oscillations, which play important roles in long-term memory and working memory function respectively. SWA disruptions might lead to memory disturbances often experienced by older adults. We conducted behavioral tests in young and older C57BL/6 J mice. SWA was monitored using
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Elevated protease-activated receptor 4 (PAR4) gene expression in Alzheimer’s disease predicts cognitive decline Neurobiol. Aging (IF 3.7) Pub Date : 2024-04-21 Rebecca L. Winfree, Kevin Erreger, Jared Phillips, Mabel Seto, Yanling Wang, Julie A. Schneider, David A. Bennett, Matthew S. Schrag, Timothy J. Hohman, Heidi E. Hamm
Platelet activation of protease-activated receptor 4 (PAR4) and thrombin are at the top of a chain of events leading to fibrin deposition, microinfarcts, blood-brain barrier disruption, and inflammation. We evaluated mRNA expression of the PAR4 gene in human brain and global cognitive performance in participants with and without cognitive impairment or dementia. Data were acquired from the Religious
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The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging Neurobiol. Aging (IF 3.7) Pub Date : 2024-04-18 Charly Hugo Alexandre Billaud, Junhong Yu
Alterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (age=73 ± 8)
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Association of APOE genotype with blood-brain barrier permeability in neurodegenerative disorders Neurobiol. Aging (IF 3.7) Pub Date : 2024-04-10 Ilenia Libri, Chiara Silvestri, Salvatore Caratozzolo, Antonella Alberici, Andrea Pilotto, Silvana Archetti, Laura Trainini, Barbara Borroni, Alessandro Padovani, Alberto Benussi
is recognized for its role in modulating blood-brain barrier (BBB) permeability , which may have significant implications for the pathogenesis and progression of neurodegenerative disorders. However, evidence is contrasting. This study explores the impact of genotypes on BBB integrity among 230 participants experiencing cognitive impairment, encompassing cases of Alzheimer's disease (AD) as well as
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Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with abnormalities in white matter structural integrity and connectivity: An ex-vivo diffusion MRI and pathology investigation Neurobiol. Aging (IF 3.7) Pub Date : 2024-04-10 Mahir Tazwar, Arnold M. Evia, Abdur Raquib Ridwan, Sue E. Leurgans, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis
Limbic predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is common in older adults and is associated with neurodegeneration, cognitive decline and dementia. In this MRI and pathology investigation we tested the hypothesis that LATE-NC is associated with abnormalities in white matter structural integrity and connectivity of a network of brain regions typically harboring
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Brain oscillatory processes related to sequence memory in healthy older adults Neurobiol. Aging (IF 3.7) Pub Date : 2024-04-06 Nina M. Ehrhardt, Agnes Flöel, Shu-Chen Li, Guglielmo Lucchese, Daria Antonenko
Sequence memory is subject to age-related decline, but the underlying processes are not yet fully understood. We analyzed electroencephalography (EEG) in 21 healthy older (60–80 years) and 26 young participants (20–30 years) and compared time-frequency spectra and theta-gamma phase-amplitude-coupling (PAC) during encoding of the order of visually presented items. In older adults, desynchronization
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Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer’s disease Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-30 Umberto Nencha, Isotta Rigoni, Federica Ribaldi, Daniele Altomare, Margitta Seeck, Valentina Garibotto, Serge Vulliémoz, Giovanni B. Frisoni
We assessed the relationship of gamma oscillations with tau deposition in Alzheimer’s disease (AD) and other cognitive diseases, as both are altered during the disease course and relate to neurodegeneration. We retrospectively analyzed data from 7 AD, tau positive patients and 9 tau negative patients, who underwent cerebral amyloid PET and tau PET, and EEG within 12 months. Relative gamma power was
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Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-30 Arunima Kapoor, Shubir Dutt, John Paul M. Alitin, Isabel J. Sible, Anisa Marshall, Fatemah Shenasa, Allison C. Engstrom, Aimée Gaubert, Xingfeng Shao, David Robert Bradford, Kathleen Rodgers, Mara Mather, Danny J.J. Wang, Daniel A. Nation
Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as white matter hyperintensities (WMH). Moreover, apolipoprotein-e4 () carriers at genetic risk for Alzheimer’s disease exhibit cerebrovascular dysfunction relative to non-carriers. We examined whether older adults, and carriers specifically, with diminished CVR would exhibit higher WMH burden. Independently living
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Apolipoprotein E and Alzheimer’s disease pathology in African American older adults Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-30 Sarah K. Royse, Beth E. Snitz, Ashley V. Hill, Alexandria C. Reese, Rebecca E. Roush, M. Ilyas Kamboh, Marnie Bertolet, Anum Saeed, Brian J. Lopresti, Victor L. Villemagne, Oscar L. Lopez, Steven E. Reis, James T. Becker, Ann D. Cohen
The apolipoprotein-E4 () and apolipoprotein-E2 (*2) alleles are more common in African American versus non-Hispanic white populations, but relationships of both alleles with Alzheimer’s disease (AD) pathology among African American individuals are unclear. We measured allele and β-amyloid (Aβ) and tau using blood samples and positron emission tomography (PET) images, respectively. Individual regression
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Trajectories of amyloid beta accumulation – Unveiling the relationship with APOE genotype and cognitive decline Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-29 Maha Wybitul, Andreas Buchmann, Nicolas Langer, Christoph Hock, Valerie Treyer, Anton Gietl, for the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
Amyloid beta (Aβ) follows a sigmoidal time function with varying accumulation rates. We studied how the position on this function, reflected by different Aβ accumulation phases, influences ɛ4’s association with Aβ and cognitive decline in 503 participants without dementia using Aβ-PET imaging over 5.3-years. First, Aβ load and accumulation were analyzed irrespective of phases using linear mixed regression
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Decomposing neurophysiological underpinnings of age-related decline in visual working memory Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-20 Marius Tröndle, Nicolas Langer
Exploring the neural basis of age-related decline in working memory is vital in our aging society. Previous electroencephalographic studies suggested that the contralateral delay activity (CDA) may be insensitive to age-related decline in lateralized visual working memory (VWM) performance. Instead, recent evidence indicated that task-induced alpha power lateralization decreases in older age. However
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Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-15 Neda Shafiee, Vladimir Fonov, Mahsa Dadar, R. Nathan Spreng, D. Louis Collins
Nucleus Basalis of Meynert (NbM), a crucial source of cholinergic projection to the entorhinal cortex (EC) and hippocampus (HC), has shown sensitivity to neurofibrillary degeneration in the early stages of Alzheimer’s Disease. Using deformation-based morphometry (DBM) on up-sampled MRI scans from 1447 Alzheimer’s Disease Neuroimaging Initiative participants, we aimed to quantify NbM degeneration along
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Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-13 Ryo Inagaki, Tohru Yamakuni, Takashi Saito, Takaomi C. Saido, Shigeki Moriguchi
Brazilian green propolis (propolis) is a chemically complex resinous substance that is a potentially viable therapeutic agent for Alzheimer’s disease. Herein, propolis induced a transient increase in intracellular Ca concentration ([Ca]) in Neuro-2A cells; moreover, propolis-induced [Ca] elevations were suppressed prior to 24-h pretreatment with amyloid-β. To reveal the effect of [Ca] elevation on
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Brain age of rhesus macaques over the lifespan Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-09 Yang S. Liu, Madhura Baxi, Christopher R. Madan, Kevin Zhan, Nikolaos Makris, Douglas L. Rosene, Ronald J. Killiany, Suheyla Cetin-Karayumak, Ofer Pasternak, Marek Kubicki, Bo Cao
Through the application of machine learning algorithms to neuroimaging data the brain age methodology was shown to provide a useful individual-level biological age prediction and identify key brain regions responsible for the prediction. In this study, we present the methodology of constructing a rhesus macaque brain age model using a machine learning algorithm and discuss the key predictive brain
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The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-04 María Rodriguez-Ayllon, Alexander Neumann, Amy Hofman, Meike W. Vernooij, Julia Neitzel
Physical activity is a protective factor against brain atrophy, while loss of brain volume could also be a determinant of physical activity. Therefore, we aimed to explore the bidirectional association of physical activity with brain structures in middle-aged and older adults from the UK Biobank. Overall, 3027 participants (62.45 ± 7.27 years old, 51.3% females) had data at two time points. Hippocampal
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Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-02 Lisa Bransby, Nawaf Yassi, Emily Rosenich, Rachel Buckley, Qiao-Xin Li, Paul Maruff, Matthew Pase, Yen Ying Lim
This study aimed to determine associations between modifiable dementia risk factors (MDRF), across domains mood symptomatology, lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology, with cognition, beta-amyloid (Aβ) and tau, and brain volume. Middle-aged/older adults (n=82) enrolled in a sub-study of the Healthy Brain Project completed self-report
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Psychosis in Alzheimer’s disease is associated with specific changes in brain MRI volume, cognition and neuropathology Neurobiol. Aging (IF 3.7) Pub Date : 2024-03-02 Francisco C. Almeida, Tiago Jesus, Ana Coelho, Miguel Quintas-Neves, Kathryn Gauthreaux, Merilee A. Teylan, Charles N. Mock, Walter A. Kukull, John F. Crary, Tiago Gil Oliveira
Psychosis in Alzheimer’s Disease (AD) is prevalent and indicates poor prognosis. However, the neuropathological, cognitive and brain atrophy patterns underlying these symptoms have not been fully elucidated. In this study, we evaluated 178 patients with AD neuropathological change (ADNC) and ante-mortem volumetric brain magnetic resonance imaging (MRI). Presence of psychosis was determined using the
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Differences in scalp-to-cortex tissues across age groups, sexes and brain regions: Implications for neuroimaging and brain stimulation techniques Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-29 Sybren Van Hoornweder, Marc Geraerts, Stefanie Verstraelen, Marten Nuyts, Kevin A. Caulfield, Raf Meesen
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The association between posterior resting-state EEG alpha rhythms and functional MRI connectivity in older adults with subjective memory complaint Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-28 Susanna Lopez, Harald Hampel, Patrizia Andrea Chiesa, Claudio Del Percio, Giuseppe Noce, Roberta Lizio, Stefan J. Teipel, Martin Dyrba, Gabriel González-Escamilla, Hovagim Bakardjian, Enrica Cavedo, Simone Lista, Andrea Vergallo, Pablo Lemercier, Giuseppe Spinelli, Michel J. Grothe, Marie-Claude Potier, Fabrizio Stocchi, Raffaele Ferri, Marie-Odile Habert, Bruno Dubois, Claudio Babiloni, INSIGHT-preAD
Resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are dominant in posterior cortical areas in healthy adults and are abnormal in subjective memory complaint (SMC) persons with Alzheimer’s disease amyloidosis. This exploratory study in 161 SMC participants tested the relationships between those rhythms and seed-based resting-state functional magnetic resonance imaging (rs-fMRI)
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Cytokine profiling in senescent and reactive astrocytes: A systematic review Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-27 Michel López-Teros, Adriana Alarcón-Aguilar, Alejandra Castillo-Aragón, Mina Königsberg, Armando Luna-López
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Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-23 Alexandra M. Gaynor, Yunglin Gazes, Caleb R. Haynes, Reshma S. Babukutty, Christian Habeck, Yaakov Stern, Yian Gu
Greater engagement in cognitively stimulating activities (CSA) during adulthood has been shown to protect against neurocognitive decline, but no studies have investigated whether CSA during childhood protects against effects of brain changes on cognition later in life. The current study tested the moderating role of childhood CSA in the relationships between brain structure and cognitive performance
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Personality traits and cognitive reserve—High openness benefits cognition in the presence of age-related brain changes Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-22 Annabell Coors, Seonjoo Lee, Christian Habeck, Yaakov Stern
Cognitive reserve explains differential susceptibility of cognitive performance to neuropathology. We investigated whether certain personality traits underlie cognitive reserve and are accordingly associated with better cognition and less cognitive decline in the presence of age-related brain changes. We included healthy adults aged 19–80 years for cross-sectional (N=399) and longitudinal (N=273, mean
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Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-16 James Naude, Meng Wang, Rebeca Leon, Eric Smith, Zahinoor Ismail
Mild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer’s Disease Neuroimaging Initiative
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Association of peripheral immunity and cerebral small vessel disease in older adults without dementia: A longitudinal study Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-16 Chu-Yun Xiao, Ya-Hui Ma, Yong-Li Zhao, Jia-Yao Liu, Lan Tan, on behalf of Alzheimer’s Disease Neuroimaging Initiative
This study explored the associations between peripheral immunity with cerebral small vessel diseases. Older adults without dementia from the Alzheimer’s Disease Neuroimaging Initiative were investigated. Peripheral blood was obtained, and magnetic resonance imaging was performed to measure cerebral microbleeds (CMB), lacunar infarctions (LI), and white matter hyperintensities (WMH). Multivariable-adjusted
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Lower oddball event-related EEG delta and theta responses in patients with dementia due to Parkinson's and Lewy body than Alzheimer's disease Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-16 Ebru Yıldırım, Tuba Aktürk, Lütfü Hanoğlu, Görsev Yener, Claudio Babiloni, Bahar Güntekin
Oddball task-related EEG delta and theta responses are associated with frontal executive functions, which are significantly impaired in patients with dementia due to Parkinson's disease (PDD) and Lewy bodies (DLB). The present study investigated the oddball task-related EEG delta and theta responses in patients with PDD, DLB, and Alzheimer's disease dementia (ADD). During visual and auditory oddball
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Associations of brain morphology with cortical proteins of cognitive resilience Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-15 Victoria N. Poole, Abdur R. Ridwan, Konstantinos Arfanakis, Robert J. Dawe, Nicholas T. Seyfried, Philip L. De Jager, Julie A. Schneider, Sue E. Leurgans, Lei Yu, David A. Bennett
In a recent proteome-wide study, we identified several candidate proteins for drug discovery whose cortical abundance was associated with cognitive resilience to late-life brain pathologies. This study examines the extent to which these proteins are associated with the brain structures of cognitive resilience in decedents from the Religious Orders Study and Memory and Aging Project. Six proteins were
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Age-related differences in perception and coding of attractive odorants in mice Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-15 Laura Chalençon, Maëllie Midroit, Anna Athanassi, Marc Thevenet, Marine Breton, Jérémy Forest, Marion Richard, Anne Didier, Nathalie Mandairon
Hedonic perception deeply changes with aging, significantly impacting health and quality of life in elderly. In young adult mice, an odor hedonic signature is represented along the antero-posterior axis of olfactory bulb, and transferred to the olfactory tubercle and ventral tegmental area, promoting approach behavior. Here, we show that while the perception of unattractive odorants was unchanged in
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Physical activity-related individual differences in functional human connectome are linked to fluid intelligence in older adults Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-08 Dominika M. Pindus, Meishan Ai, Laura Chaddock-Heyman, Agnieszka Z. Burzynska, Neha P. Gothe, Elizabeth A. Salerno, Jason Fanning, Sheeba R.A. Arnold Anteraper, Alfonso N. Castanon, Susan Whitfield-Gabrieli, Charles H. Hillman, Edward McAuley, Arthur F. Kramer
The study examined resting state functional connectivity (rs-FC) associated with moderate-to-vigorous physical activity (MV-PA), sedentary time (ST), TV viewing, computer use, and their relationship to cognitive performance in older adults. We used pre-intervention data from 119 participants from the Fit & Active Seniors trial. Multivariate pattern analysis revealed two seeds associated with MV-PA:
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Volume electron microscopy reveals age-related ultrastructural differences of globular bush cell axons in mouse central auditory system Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-05 Wen-Qing Huang, Haibin Sheng, Haoyu Wang, Yumeng Qi, Fangfang Wang, Yunfeng Hua
In mammals, thick axonal calibers wrapped with heavy myelin sheaths are prevalent in the auditory nervous system. These features are crucial for fast traveling of nerve impulses with minimal attenuation required for sound signal transmission. In particular, the long-range projections from the cochlear nucleus – the axons of globular bush cells (GBCs) – to the medial nucleus of the trapezoid body (MNTB)
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Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-05 Nina Karalija, Goran Papenberg, Jarkko Johansson, Anders Wåhlin, Alireza Salami, Micael Andersson, Jan Axelsson, Dmitry Kuznetsov, Katrine Riklund, Martin Lövdén, Ulman Lindenberger, Lars Bäckman, Lars Nyberg
Dopamine decline is suggested to underlie aging-related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5-year longitudinal data for a sample of healthy, older adults (baseline: = 181, age: 64–68 years; 5-year follow-up: = 129) who underwent positron emission tomography with C-raclopride to assess dopamine D2-like receptor (DRD2) availability, magnetic
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Data-driven analysis of regional brain metabolism in behavioral frontotemporal dementia and late-onset primary psychiatric diseases with frontal lobe syndrome: A PET/MRI study Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-03 Annachiara Cagnin, Giorgio Pigato, Ilaria Pettenuzzo, Giovanni Zorzi, Beatrice Roiter, Maria Giulia Anglani, Cinzia Bussè, Stefano Mozzetta, Carlo Gabelli, Cristina Campi, Diego Cecchin
Late-onset primary psychiatric disease (PPD) and behavioral frontotemporal dementia (bvFTD) present with a similar frontal lobe syndrome. We compare brain glucose metabolism in bvFTD and late-onset PPD and investigate the metabolic correlates of cognitive and behavioral disturbances through FDG-PET/MRI. We studied 37 bvFTD and 20 late-onset PPD with a mean clinical follow-up of three years. At baseline
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Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia Neurobiol. Aging (IF 3.7) Pub Date : 2024-02-02 Adriana L. Ruiz-Rizzo, Kathrin Finke, Jessica S. Damoiseaux, Claudia Bartels, Katharina Buerger, Nicoleta Carmen Cosma, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Ingo Frommann, Wenzel Glanz, Doreen Goerss, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Debora Melo van Lent, Matthias H.J. Munk, Oliver Peters, Josef Priller, Alfredo Ramirez, Ayda