Aging is the main risk factor for age-related macular degeneration (AMD), a retinal neurodegenerative disease that leads to irreversible blindness, particularly in people over 60 years old. Retinal pigmented epithelium (RPE) atrophy is an AMD hallmark. Genome-wide chromatin accessibility, DNA methylation, and gene expression studies of AMD and control RPE demonstrate epigenomic/transcriptomic changes occur during AMD onset and progression. However, mechanisms by which molecular alterations of normal aging impair RPE function and contribute to AMD pathogenesis are unclear.

中文翻译：

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小鼠视网膜色素上皮的年龄和性别差异的翻译反应


衰老是年龄相关性黄斑变性 (AMD) 的主要危险因素，AMD 是一种视网膜神经退行性疾病，可导致不可逆转的失明，特别是对于 60 岁以上的人群。视网膜色素上皮 (RPE) 萎缩是 AMD 的一个标志。 AMD 和对照 RPE 的全基因组染色质可及性、DNA 甲基化和基因表达研究表明，AMD 发病和进展期间会发生表观基因组/转录组变化。然而，正常衰老的分子改变损害 RPE 功能并导致 AMD 发病机制的机制尚不清楚。