The aging population suffers from memory impairments. Slow-wave activity (SWA) is composed of slow (0.5–1 Hz) and delta (1–4 Hz) oscillations, which play important roles in long-term memory and working memory function respectively. SWA disruptions might lead to memory disturbances often experienced by older adults. We conducted behavioral tests in young and older C57BL/6 J mice. SWA was monitored using wide-field imaging with voltage sensors. Cell-specific calcium imaging was used to monitor the activity of excitatory and inhibitory neurons in these mice. Older mice exhibited impairments in working memory but not memory consolidation. Voltage-sensor imaging revealed aberrant synchronization of neuronal activity in older mice. Notably, we found older mice exhibited no significant alterations in slow oscillations, whereas there was a significant increase in delta power compared to young mice. Calcium imaging revealed hypoactivity in inhibitory neurons of older mice. Combined, these results suggest that neural activity disruptions might correlate with aberrant memory performance in older mice.

中文翻译：

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衰老小鼠模型中的慢波活动中断和记忆障碍


人口老龄化导致记忆力减退。慢波活动（SWA）由慢波（0.5-1Hz）和δ波（1-4Hz）振荡组成，分别在长期记忆和工作记忆功能中发挥重要作用。 SWA 中断可能会导致老年人经常经历的记忆障碍。我们对年轻和年长的 C57BL/6J 小鼠进行了行为测试。使用带有电压传感器的广域成像来监测 SWA。使用细胞特异性钙成像来监测这些小鼠的兴奋性和抑制性神经元的活动。年长的小鼠表现出工作记忆受损，但记忆巩固没有受损。电压传感器成像显示老年小鼠神经元活动同步异常。值得注意的是，我们发现老年小鼠的慢振荡没有显着变化，而与年轻小鼠相比，δ功率显着增加。钙成像显示老年小鼠的抑制性神经元活性低下。综合起来，这些结果表明神经活动中断可能与老年小鼠的异常记忆表现相关。