This study aimed to determine associations between modifiable dementia risk factors (MDRF), across domains mood symptomatology, lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology, with cognition, beta-amyloid (Aβ) and tau, and brain volume. Middle-aged/older adults (n=82) enrolled in a sub-study of the Healthy Brain Project completed self-report questionnaires and a neuropsychological battery. Cerebrospinal fluid levels of Aβ 1–42, total tau (t-tau), and phosphorylated tau (p-tau) (Roche Elecsys), and MRI markers of hippocampal volume and total brain volume were obtained. Participants were classified as no/single domain risk (≤1 domains) or multidomain risk (≥2 domains). Compared to the no/single domain risk group, the multidomain risk group performed worse on the Preclinical Alzheimer’s Cognitive Composite (d=0.63, p=.005), and Executive Function (d=0.50, p=.016), and had increased p-tau (d=0.47, p=.042) and t-tau (d=0.54, p=.021). In middle-aged/older adults, multidomain MDRFs were related to increases in tau and worse cognition, but not Aβ or brain volume. Findings suggest that increases in AD biomarkers are apparent in midlife, particularly for individuals with greater burden, or variety of MDRFs.

中文翻译：

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中老年人多域可改变痴呆危险因素与 AD 生物标志物和认知之间的关联

本研究旨在确定可改变的痴呆风险因素 (MDRF) 与情绪症状学、生活方式行为、心血管疾病、认知/社会参与、睡眠障碍/症状学、认知、β-淀粉样蛋白 (Aβ) 和 tau 蛋白以及大脑等领域之间的关联体积。参加健康大脑项目子研究的中年/老年人 (n=82) 完成了自我报告问卷和神经心理学电池。获得脑脊液中 Aβ 1-42、总 tau (t-tau) 和磷酸化 tau (p-tau) (Roche Elecsys) 的水平，以及海马体积和总脑体积的 MRI 标记。参与者被分为无/单域风险（≤1 个域）或多域风险（≥2 个域）。与无/单域风险组相比，多域风险组在临床前阿尔茨海默病认知综合（d=0.63，p=.005）和执行功能（d=0.50，p=.016）上表现较差，并且有所增加p-tau (d=0.47，p=.042) 和 t-tau (d=0.54，p=.021)。在中年/老年人中，多域 MDRF 与 tau 蛋白增加和认知能力较差有关，但与 Aβ 或脑容量无关。研究结果表明，AD 生物标志物的增加在中年时很明显，特别是对于负担较重或 MDRF 种类较多的个体。