The study examined resting state functional connectivity (rs-FC) associated with moderate-to-vigorous physical activity (MV-PA), sedentary time (ST), TV viewing, computer use, and their relationship to cognitive performance in older adults. We used pre-intervention data from 119 participants from the Fit & Active Seniors trial. Multivariate pattern analysis revealed two seeds associated with MV-PA: right superior frontal gyrus (SFG; spanning frontoparietal [FPN] and ventral attention networks [VAN]) and right precentral (PrG) and postcentral gyri (PoG) of the somatosensory network (SN). A positive correlation between the right SFG seed and a cluster spanning default mode (DMN), dorsal attention (DAN), FPN, and visual networks (VIS) was linked to higher fluid intelligence, as was FC between the right PrG/PoG seed and a cluster in VIS. No significant rs-FC patterns associated with ST, TV viewing, or computer use were found. Our findings suggest that greater functional integration within networks implementing top-down control and within those supporting visuospatial abilities, paired with segregation between networks critical and those not critical to top-down control, may help promote cognitive reserve in more physically active seniors.

中文翻译：

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人体功能连接组中与体力活动相关的个体差异与老年人的流体智力有关

该研究检查了与中度至剧烈体力活动（MV-PA）、久坐时间（ST）、电视观看、电脑使用相关的静息状态功能连接（rs-FC）及其与老年人认知表现的关系。我们使用了来自 Fit & Active Seniors 试验的 119 名参与者的干预前数据。多变量模式分析揭示了与 MV-PA 相关的两个种子：右额上回（SFG；跨越额顶叶 [FPN] 和腹侧注意网络 [VAN]）以及体感网络 (SN) 的右中央前回 (PrG) 和中央后回 (PoG) ）。右侧 SFG 种子与跨越默认模式 (DMN)、背侧注意力 (DAN)、FPN 和视觉网络 (VIS) 的集群之间的正相关性与较高的流体智力相关，右侧 PrG/PoG 种子与右侧 PrG/PoG 种子之间的 FC 也是如此。 VIS 中的一个集群。没有发现与 ST、电视观看或计算机使用相关的显着 rs-FC 模式。我们的研究结果表明，实施自上而下控制的网络和支持视觉空间能力的网络内更大的功能整合，再加上对自上而下控制至关重要的网络和不重要的网络之间的隔离，可能有助于促进身体活跃的老年人的认知储备。