Alterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (age=73 ± 8) from the Alzheimer’s Disease Neuroimaging Initiative, cortical regions associated with memory (Rey Auditory Verbal Learning Test) were identified using Lasso regression. Two structural equation models (SEM), for SC and resting-state FC, were fitted including CT areas, and SC and FC to the left and right hippocampus (LHIP,RHIP). LHIP (=-0.150,=<.001) and RHIP (=-0.139,=<.001) SC predicted left temporopolar/rhinal CT; RHIP SC predicted right temporopolar/rhinal CT (=-0.191,=<.001). LHIP SC predicted right fusiform/parahippocampal (=-0.104,=.011) and intraparietal sulcus/superior parietal CT (=0.101,=.028). Increased RHIP FC predicted higher left inferior parietal CT (=0.132,=.042) while increased LHIP FC predicted lower right fusiform/parahippocampal CT (=-0.97; =.023). The hippocampi may be epicentres for cortical thinning through disrupted connectivity.

中文翻译：

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海马体作为神经认知衰老中远端皮质变薄的结构和功能网络中心

灰质 (GM) 和白质 (WM) 的变化与整个神经认知衰老谱系的记忆障碍有关，理论上会传播到整个大脑网络。功能和结构连接（FC、SC）可以解释广泛的萎缩。我们测试了 SC 和 FC 对海马体连接区域皮质厚度 (CT) 的影响。在来自阿尔茨海默氏病神经影像计划的 419 名 (223 F) 参与者（年龄 = 73 ± 8）中，使用 Lasso 回归识别了与记忆相关的皮层区域（Rey 听觉语言学习测试）。拟合 SC 和静息态 FC 的两个结构方程模型 (SEM)，包括 CT 区域以及左右海马 (LHIP、RHIP) 的 SC 和 FC。 LHIP (=-0.150,=<.001) 和 RHIP (=-0.139,=<.001) SC 预测左颞极/鼻 CT； RHIP SC 预测右颞极/鼻 CT (=-0.191,=<.001)。 LHIP SC 预测右侧梭状/海马旁 (=-0.104,=.011) 和顶内沟/顶上 CT (=0.101,=.028)。 RHIP FC 增加预测左下顶叶 CT 较高 (=0.132,=.042)，而 LHIP FC 增加则预测右下梭状/海马旁 CT (=-0.97;=.023)。海马体可能是由于连接中断而导致皮质变薄的中心。