The apolipoprotein-E4 () and apolipoprotein-E2 (*2) alleles are more common in African American versus non-Hispanic white populations, but relationships of both alleles with Alzheimer’s disease (AD) pathology among African American individuals are unclear. We measured allele and β-amyloid (Aβ) and tau using blood samples and positron emission tomography (PET) images, respectively. Individual regression models tested associations of each allele with Aβ or tau PET overall, stratified by racialized group, and with a racialized group interaction. We included 358 older adults (42% African American) with Aβ PET, 134 (29% African American) of whom had tau PET. was associated with higher Aβ in non-Hispanic white ( < 0.0001), but not African American ( = 0.64) participants; racialized group modified the association between and Aβ ( < 0.0001). There were no other racialized group differences. These results suggest that the association of and Aβ differs between African American and non-Hispanic white populations. Other drivers of AD pathology in African American populations should be identified as potential therapeutic targets.

中文翻译：

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非裔美国老年人的载脂蛋白 E 和阿尔茨海默病病理学

载脂蛋白-E4 () 和载脂蛋白-E2 (*2) 等位基因在非裔美国人中比非西班牙裔白人更常见，但这两个等位基因与非裔美国人中阿尔茨海默病 (AD) 病理学的关系尚不清楚。我们分别使用血液样本和正电子发射断层扫描 (PET) 图像测量等位基因、β-淀粉样蛋白 (Aβ) 和 tau 蛋白。个体回归模型测试了每个等位基因与 Aβ 或 tau PET 整体的关联性，按种族群体分层，并与种族群体相互作用进行分层。我们纳入了 358 名接受 Aβ PET 的老年人（42% 非裔美国人），其中 134 名（29% 非裔美国人）接受了 tau PET。与非西班牙裔白人 (< 0.0001) 较高的 Aβ 相关，但与非洲裔美国人 (= 0.64) 参与者无关；种族化群体改变了 和 Aβ 之间的关联 (<0.0001)。不存在其他种族群体差异。这些结果表明，Aβ 和 Aβ 的关联在非裔美国人和非西班牙裔白人群体中存在差异。非裔美国人群体 AD 病理的其他驱动因素应被确定为潜在的治疗目标。