We assessed the relationship of gamma oscillations with tau deposition in Alzheimer’s disease (AD) and other cognitive diseases, as both are altered during the disease course and relate to neurodegeneration. We retrospectively analyzed data from 7 AD, tau positive patients and 9 tau negative patients, who underwent cerebral amyloid PET and tau PET, and EEG within 12 months. Relative gamma power was higher in tau positive (AD) patients than in tau negative patients (p < .05). In tau positive AD patients, tau burden was associated with a linear increase in gamma power (p < .05), while no association was present in the tau negative group nor with amyloid-β burden in either group. Thus, increase in the gamma power might represent a novel biomarker for tau driven neurodegeneration.

中文翻译：

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伽玛频率振荡的变化与阿尔茨海默病中皮质 tau 沉积相关

我们评估了阿尔茨海默病 (AD) 和其他认知疾病中 γ 振荡与 tau 蛋白沉积的关系，因为两者在疾病过程中都会发生变化，并且与神经退行性疾病相关。我们回顾性分析了 7 名 AD、tau 阳性患者和 9 名 tau 阴性患者的数据，这些患者在 12 个月内接受了脑淀粉样蛋白 PET 和 tau PET 以及脑电图检查。 tau 阳性 (AD) 患者的相对伽马功率高于 tau 阴性患者 (p < .05)。在 tau 阳性 AD 患者中，tau 负荷与 γ 功率线性增加相关 (p < .05)，而 tau 阴性组中不存在相关性，且与任一组中的淀粉样蛋白-β 负荷均不存在相关性。因此，伽马功率的增加可能代表 tau 驱动的神经变性的新生物标志物。