Resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are dominant in posterior cortical areas in healthy adults and are abnormal in subjective memory complaint (SMC) persons with Alzheimer’s disease amyloidosis. This exploratory study in 161 SMC participants tested the relationships between those rhythms and seed-based resting-state functional magnetic resonance imaging (rs-fMRI) connectivity between thalamus and visual cortical networks as a function of brain amyloid burden, revealed by positron emission tomography and cognitive reserve, measured by educational attainment. The SMC participants were divided into 4 groups according to 2 factors: Education (Edu+ and Edu-) and Amyloid burden (Amy+ and Amy-). There was a statistical interaction (p < 0.05) between the two factors, and the subgroup analysis using estimated marginal means showed a positive association between the mentioned rs-fMRI connectivity and the posterior rsEEG alpha rhythms in the SMC participants with low brain amyloidosis and high CR (Amy-/Edu+). These results suggest that in SMC persons, early Alzheimer’s disease amyloidosis may contrast the beneficial effects of cognitive reserve on neurophysiological oscillatory mechanisms at alpha frequencies and connectivity between the thalamus and visual cortical networks.

中文翻译：

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主观记忆抱怨老年人后静息态脑电图α节律与功能性MRI连接之间的关联

静息状态闭眼脑电图 (rsEEG) α 节律在健康成人的后皮质区域占主导地位，而在患有阿尔茨海默病淀粉样变性的主观记忆抱怨 (SMC) 患者中则异常。这项针对 161 名 SMC 参与者的探索性研究测试了这些节律与丘脑和视觉皮层网络之间基于种子的静息态功能磁共振成像 (rs-fMRI) 连接之间的关系，作为大脑淀粉样蛋白负荷的函数，通过正电子发射断层扫描和认知储备，通过教育程度来衡量。SMC 参与者根据 2 个因素分为 4 组：教育（Edu+ 和 Edu-）和淀粉样蛋白负担（Amy+ 和 Amy-）。两个因素之间存在统计交互作用 (p < 0.05)，并且使用估计边际平均值进行的亚组分析显示，在具有低脑淀粉样变性和高脑淀粉样变性的 SMC 参与者中，上述 rs-fMRI 连接性与后 rsEEG α 节律之间呈正相关。 CR（艾米-/Edu+）。这些结果表明，在 SMC 人群中，早期阿尔茨海默病淀粉样变性可能会对比认知储备对 α 频率的神经生理振荡机制以及丘脑和视觉皮层网络之间的连接的有益影响。