Platelet activation of protease-activated receptor 4 (PAR4) and thrombin are at the top of a chain of events leading to fibrin deposition, microinfarcts, blood-brain barrier disruption, and inflammation. We evaluated mRNA expression of the PAR4 gene in human brain and global cognitive performance in participants with and without cognitive impairment or dementia. Data were acquired from the Religious Orders Study (ROS) and the Rush Memory and Aging Project (MAP).

中文翻译：

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阿尔茨海默病中蛋白酶激活受体 4 (PAR4) 基因表达升高预示认知能力下降


蛋白酶激活受体 4 (PAR4) 和凝血酶的血小板激活是导致纤维蛋白沉积、微梗死、血脑屏障破坏和炎​​症的一系列事件的最重要部分。我们评估了人脑中 PAR4 基因的 mRNA 表达以及患有或不患有认知障碍或痴呆的参与者的整体认知表现。数据来自宗教团体研究 (ROS) 和 Rush 记忆与衰老项目 (MAP)。