Mild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer’s Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside corresponding p-tau and A. Two meta-regions of interest were generated to represent Braak I and III neuropathological stages. Multivariable linear regression modelled the association between MBI as independent variable and tau tracer uptake as dependent variable. Among A positive individuals, MBI was associated with tau uptake in Braak I (=0.45(0.15), 01) and Braak III (=0.24(0.07), 01) regions. In A negative individuals, MBI was not associated with tau in the Braak I region (p=0.11) with a negative association in Braak III (01). These findings suggest MBI may be a sequela of neurodegeneration, and can be implemented as a cost-effective framework to help improve screening efficiency for AD.

中文翻译：

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早期皮质阿尔茨海默病大脑区域的 Tau-PET 与患有正常认知或轻度认知障碍的老年人的轻度行为障碍有关

轻度行为障碍 (MBI) 利用晚年出现的突发性和持续性神经精神症状 (NPS) 来识别发生痴呆的高危人群。磷酸化 tau (p-tau) 是阿尔茨海默病 (AD) 的标志性生物学表现。我们研究了早期 AD 皮质区域中 MBI 与 tau 蛋白积累之间的关联。在 442 名认知正常或轻度认知障碍的阿尔茨海默病神经影像计划参与者中，MBI 状态与相应的 p-tau 和 A 一起确定。生成了两个感兴趣的元区域来代表 Braak I 和 III 神经病理学阶段。多变量线性回归对作为自变量的 MBI 和作为因变量的 tau 示踪剂摄取之间的关联进行建模。在 A 阳性个体中，MBI 与 Braak I (=0.45(0.15), 01) 和 Braak III (=0.24(0.07), 01) 区域的 tau 摄取相关。在 A 阴性个体中，MBI 与 Braak I 区域中的 tau 蛋白无关 (p=0.11)，而与 Braak III 区域中的 tau 蛋白呈负相关 (01)。这些发现表明 MBI 可能是神经退行性疾病的后遗症，并且可以作为一种具有成本效益的框架来实施，以帮助提高 AD 的筛查效率。