Oddball task-related EEG delta and theta responses are associated with frontal executive functions, which are significantly impaired in patients with dementia due to Parkinson's disease (PDD) and Lewy bodies (DLB). The present study investigated the oddball task-related EEG delta and theta responses in patients with PDD, DLB, and Alzheimer's disease dementia (ADD). During visual and auditory oddball paradigms, EEG activity was recorded in 20 ADD, 17 DLB, 20 PDD, and 20 healthy (HC) older adults. Event-related EEG power spectrum and phase-locking analysis were performed at the delta (1–4 Hz) and theta (4–7 Hz) frequency bands for target and nontarget stimuli. Compared to the HC persons, dementia groups showed lower frontal and central delta and theta power and phase-locking associated with task performance and neuropsychological test scores. Notably, this effect was more significant in the PDD and DLB than in the ADD. In conclusion, oddball task-related frontal and central EEG delta and theta responses may reflect frontal supramodal executive dysfunctions in PDD and DLB patients.

中文翻译：

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与阿尔茨海默病相比，帕金森病和路易体痴呆患者与奇怪事件相关的脑电图 delta 和 theta 反应较低

奇怪的任务相关脑电图 delta 和 theta 反应与额叶执行功能相关，而帕金森病 (PDD) 和路易体 (DLB) 导致的痴呆患者的额叶执行功能显着受损。本研究调查了 PDD、DLB 和阿尔茨海默病痴呆 (ADD) 患者与奇怪任务相关的脑电图 delta 和 theta 反应。在视觉和听觉奇怪范式中，记录了 20 名 ADD、17 名 DLB、20 名 PDD 和 20 名健康 (HC) 老年人的脑电图活动。在目标和非目标刺激的 delta (1-4 Hz) 和 theta (4-7 Hz) 频段进行事件相关的 EEG 功率谱和锁相分析。与 HC 人群相比，痴呆症组表现出较低的额叶和中央 delta 和 theta 功率以及与任务表现和神经心理学测试分数相关的锁相。值得注意的是，这种效应在 PDD 和 DLB 中比在 ADD 中更显着。总之，奇怪的任务相关的额叶和中央脑电图 delta 和 theta 反应可能反映了 PDD 和 DLB 患者的额叶超模态执行功能障碍。